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血清抵抗素水平升高而不是 G-CSF 水平升高与重度抑郁症的病理生理学有关:来自病例对照研究的结果。

Increased serum resistin but not G-CSF levels are associated in the pathophysiology of major depressive disorder: Findings from a case-control study.

机构信息

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Department of Psychiatry, Bangabandhu Sheikh Mujib Medical University, Shahabagh, Dhaka, Bangladesh.

出版信息

PLoS One. 2022 Feb 25;17(2):e0264404. doi: 10.1371/journal.pone.0264404. eCollection 2022.

Abstract

BACKGROUND

Many studies have predicted major depressive disorder (MDD) as the leading cause of global health by 2030 due to its high prevalence, disability, and illness. However, the actual pathophysiological mechanism behind depression is unknown. Scientists consider alterations in cytokines might be tools for understanding the pathogenesis and treatment of MDD. Several past studies on several inflammatory cytokine expressions in MDD reveal that an inflammatory process is activated, although the precise causes of that changes in cytokine levels are unclear. Therefore, we aimed to investigate resistin and G-CSF in MDD patients and controls to explore their role in the pathogenesis and development of depression.

METHODS

We included 220 participants in this study. Among them, 108 MDD patients and 112 age-sex matched healthy control (HCs). We used DSM-5 to evaluate study participants. Also, we applied the Ham-D rating scale to assess the severity of patients. Serum resistin and G-CSF levels were measured using ELISA kits (BosterBio, USA).

RESULTS

The present study observed increased serum resistin levels in MDD patients compared to HCs (13.82 ± 1.24ng/mL and 6.35 ± 0.51ng/mL, p <0.001). However, we did not find such changes for serum G-CSF levels between the groups. Ham-D scores showed a significant correlation with serum resistin levels but not G-CSF levels in the patient group. Furthermore, ROC analysis showed a fairly predictive performance of serum resistin levels in major depression (AUC = 0.746).

CONCLUSION

The present study findings suggest higher serum resistin levels are associated with the pathophysiology of MDD. This elevated serum resistin level may serve as an early risk assessment indicator for MDD. However, the role of serum G-CSF in the development of MDD is still unclear despite its neuroprotective and anti-inflammatory effects.

摘要

背景

由于其高患病率、残疾和疾病,许多研究预测到 2030 年,重度抑郁症(MDD)将成为全球健康的主要原因。然而,抑郁症背后的实际病理生理机制尚不清楚。科学家们认为细胞因子的改变可能是理解 MDD 发病机制和治疗方法的工具。过去有几项关于 MDD 中几种炎症细胞因子表达的研究表明,炎症过程被激活,尽管细胞因子水平变化的确切原因尚不清楚。因此,我们旨在研究 MDD 患者和对照者中的抵抗素和 G-CSF,以探讨它们在抑郁症发病机制和发展中的作用。

方法

我们纳入了 220 名研究参与者。其中,108 名 MDD 患者和 112 名年龄和性别匹配的健康对照者(HCs)。我们使用 DSM-5 评估研究参与者,同时使用汉密尔顿抑郁量表(Ham-D)评定量表评估患者的严重程度。采用 ELISA 试剂盒(BosterBio,美国)检测血清抵抗素和 G-CSF 水平。

结果

本研究观察到 MDD 患者的血清抵抗素水平高于 HCs(13.82±1.24ng/mL 和 6.35±0.51ng/mL,p<0.001)。然而,我们没有发现两组间血清 G-CSF 水平有这样的变化。Ham-D 评分与患者组的血清抵抗素水平显著相关,但与 G-CSF 水平无关。此外,ROC 分析显示血清抵抗素水平对 MDD 具有较好的预测性能(AUC=0.746)。

结论

本研究结果表明,较高的血清抵抗素水平与 MDD 的病理生理学有关。这种升高的血清抵抗素水平可能作为 MDD 的早期风险评估指标。然而,尽管 G-CSF 具有神经保护和抗炎作用,但它在 MDD 发展中的作用仍不清楚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0a1/8880862/28abd85e6233/pone.0264404.g001.jpg

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