Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Breast Cancer Res Treat. 2010 Dec;124(3):821-5. doi: 10.1007/s10549-010-0910-3. Epub 2010 May 1.
Interleukin-1β (IL-1β), which is involved in inflammatory and immunological responses, plays an important role in the development and progression of breast cancer. Three functional single nucleotide polymorphisms (SNPs) identified in IL-1β gene are thought to influence breast cancer risk. The results of the association between IL-1β polymorphisms and breast cancer remain inconsistent. Therefore, we conducted a meta-analysis of eight case-control studies with rs1143627 (T > C), rs16944 (C > T), and rs1143634 (C > T). We found that the variant CC genotype of rs1143627 was associated with a significantly increased breast cancer risk (CC vs. TT: OR = 1.37, 95% CI = 1.10-1.70, P = 0.22 for heterogeneity; the recessive model CC vs. TT/TC: OR = 1.40, 95% CI = 1.17-1.67, P = 0.49 for heterogeneity). For rs16944 (C > T) and rs1143634 (C > T), no significant associations were found in all genetic models. In conclusion, the present meta-analysis suggests that rs1143627 is associated with breast cancer risk.
白细胞介素-1β（IL-1β）参与炎症和免疫反应，在乳腺癌的发生和发展中起着重要作用。IL-1β 基因中鉴定出的三个功能单核苷酸多态性（SNP）被认为会影响乳腺癌风险。IL-1β 多态性与乳腺癌之间的关联结果仍不一致。因此，我们对 8 项病例对照研究进行了荟萃分析，涉及 rs1143627（T > C）、rs16944（C > T）和 rs1143634（C > T）。我们发现 rs1143627 的变异 CC 基因型与乳腺癌风险显著增加相关（CC 与 TT：OR = 1.37，95%CI = 1.10-1.70，P = 0.22 异质性；隐性模型 CC 与 TT/TC：OR = 1.40，95%CI = 1.17-1.67，P = 0.49 异质性）。对于 rs16944（C > T）和 rs1143634（C > T），在所有遗传模型中均未发现显著相关性。总之，本荟萃分析表明 rs1143627 与乳腺癌风险相关。
