出生在维持静止神经干细胞中的意义。
Significance of birth in the maintenance of quiescent neural stem cells.
作者信息
Kawase Koya, Nakamura Yasuhisa, Wolbeck Laura, Takemura Shoko, Zaitsu Kei, Ando Takehiro, Jinnou Hideo, Sawada Masato, Nakajima Chikako, Rydbirk Rasmus, Gokenya Sakura, Ito Akira, Fujiyama Hitomi, Saito Akari, Iguchi Akira, Kratimenos Panagiotis, Ishibashi Nobuyuki, Gallo Vittorio, Iwata Osuke, Saitoh Shinji, Khodosevich Konstantin, Sawamoto Kazunobu
机构信息
Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
出版信息
Sci Adv. 2025 Jan 24;11(4):eadn6377. doi: 10.1126/sciadv.adn6377. Epub 2025 Jan 22.
Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs. Preterm birth impairs this cellular process, leading to transient hyperactivation of RG. Consequently, in the postnatal brain, the NSC pool is depleted and neurogenesis is decreased. We also found that the maintenance of quiescent RG after preterm birth improves postnatal neurogenesis. This study demonstrates the significance of birth in the maintenance of quiescent NSCs.
出生是动物最重要的生命事件之一。然而，其在发育过程中的重要性尚未得到充分理解。在这里，我们发现，胚胎神经干细胞（NSCs）即放射状胶质细胞（RG）中谷氨酰胺代谢因出生而发生的改变，是产后NSCs进入静止状态并长期维持所必需的。早产会损害这一细胞过程，导致RG短暂过度激活。因此，在产后大脑中，NSC池会减少，神经发生也会减少。我们还发现，早产之后维持静止的RG可改善产后神经发生。这项研究证明了出生在维持静止NSCs方面的重要性。
Zotero 插件