鳜鱼（Siniperca chuatsi）中pax基因家族成员的全基因组鉴定、进化及表达

Genome-wide identification, evolution and expression of pax gene family members in mandarin fish (Siniperca chuatsi).

作者信息

Han Chong, Liu Shiyan, Ye Shuzheng, Chen Kaichun, Chen Dingxian, Wang Kaifeng, Liang Weiqian, Zhong Simin, Liu Lanyuan, Li Sipeng, Chen Weijian, Li Qiang

机构信息

Key Laboratory of Conservation and Application in Biodiversity of South China, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.

State Key Laboratory of Biocontrol and School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Guangdong Provincial Key Laboratory for Aquatic Economic Animals and Guangdong Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, Sun Yat-Sen University, Guangzhou 510275, China.

出版信息

Comp Biochem Physiol Part D Genomics Proteomics. 2025 Jun;54:101423. doi: 10.1016/j.cbd.2025.101423. Epub 2025 Jan 19.

DOI:10.1016/j.cbd.2025.101423

PMID:39842301

Abstract

The pax gene family is involved in the development process through its extensive effects on cell proliferation, differentiation, and apoptosis. Herein, the whole pax gene family members of mandarin fish (Siniperca chuatsi) were first identified and characterized. By comparing pax gene family members from another 13 representative animals, an expansion of pax gene family members was observed in teleosts. In mandarin fish, a total of 15 potential pax gene family members, distributed on 13 chromosomes, were found, which shared conserved synteny with other teleosts. The expression profiles revealed that members of pax gene family showed time-specific expression profiles during embryonic and gonad development in mandarin fish, which indicated they might play a specific role in organogenesis during embryonic development and the process of gonad development and differentiation. Our research will lay a good foundation for further functional investigation of pax gene family during fish embryonic and gonad development.

摘要

Pax基因家族通过对细胞增殖、分化和凋亡的广泛影响而参与发育过程。在此，首次鉴定并表征了鳜鱼（Siniperca chuatsi）的整个Pax基因家族成员。通过比较另外13种代表性动物的Pax基因家族成员，发现硬骨鱼中Pax基因家族成员有扩张现象。在鳜鱼中，共发现15个潜在的Pax基因家族成员，分布在13条染色体上，它们与其他硬骨鱼具有保守的共线性。表达谱显示，Pax基因家族成员在鳜鱼胚胎和性腺发育过程中呈现出时间特异性表达谱，这表明它们可能在胚胎发育期间的器官发生以及性腺发育和分化过程中发挥特定作用。我们的研究将为进一步研究Pax基因家族在鱼类胚胎和性腺发育过程中的功能奠定良好基础。