Yao Xinyan, Jia Chaoxiang, Li Anqi, Qin Ting, Peng Dai, Han Yingqian, Guo Shuang, Zhong Kai, Yang Guoyu, Wang Yueying, Li Heping
Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan province, China; Key Laboratory of Veterinary Biotechnology of Henan Province, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan, China.
Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan province, China; Key Laboratory of Veterinary Biotechnology of Henan Province, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, Henan, China.
Virology. 2025 Feb;603:110416. doi: 10.1016/j.virol.2025.110416. Epub 2025 Jan 17.
Duck Hepatitis B virus (DHBV) infection model is extensively utilized as an animal model for studying human hepatitis B virus infection and for comparative research. 557 liver samples from geese and ducks were collected in parts of Guangdong province, southern China. The overall prevalence of DHBV was 45.6% (254/557) in all samples. And the 27 complete genome sequences of DHBV strains in this study share 89.6%-100% genome-wide pairwise identity with previously identified DHBV genomes. Notably, DHBV-1, DHBV-2 and DHBV-3 of were found co-circulating among the waterfowl population in parts of Guangdong. More importantly, seven out of the 16 recombination events were determined involved DHBV sequences obtained in this study as major parent and minor parent, suggesting DHBV strains from Guangdong province play an important role in recombination events. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of DHBV.
鸭乙型肝炎病毒（DHBV）感染模型被广泛用作研究人类乙型肝炎病毒感染和进行比较研究的动物模型。在中国南方广东省部分地区采集了557份鹅和鸭的肝脏样本。所有样本中DHBV的总体流行率为45.6%（254/557）。本研究中27个DHBV毒株的完整基因组序列与先前鉴定的DHBV基因组在全基因组水平上的两两一致性为89.6%-100%。值得注意的是，在广东省部分地区的水禽群体中发现DHBV-1、DHBV-2和DHBV-3共同传播。更重要的是，在16个重组事件中，有7个确定涉及本研究获得的DHBV序列作为主要亲本和次要亲本，这表明来自广东省的DHBV毒株在重组事件中起重要作用。此外，纯化选择是作用于DHBV基因组的主要进化压力。
