Yang Yujie, Luo Junyun, Wang Shuhui, Yang Dan, Chen Shuxi, Wang Qun, Zhou Aimei
Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China.
Guangdong Zhancui Food Co. Ltd., Chaozhou 515634, China.
Int J Biol Macromol. 2025 Apr;300:140126. doi: 10.1016/j.ijbiomac.2025.140126. Epub 2025 Jan 20.
FCP-2-1, a water-soluble polysaccharide isolated and purified from Finger Citron, demonstrated hypoglycemic effect in vitro in our previous study. However, its antidiabetic effect and underlying mechanism in vivo remain to be elucidated. In this study, the antidiabetic effect of FCP-2-1 and its effects on the gut microbiota, short-chain fatty acids (SCFAs), and glucagon-like peptide-1 (GLP-1) in high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice were investigated. The results showed that FCP-2-1 could significantly alleviate diabetic symptoms in diabetic mice, restore the balance of the gut microbiota, and increase the content of acetic acid and propionic acid. In particular, FCP-2-1 was found to be able to promote the secretion of GLP-1, a new therapeutic target for diabetes. Moreover, propionic acid and FCP-2-1 were able to promote GLP-1 secretion in NCI-H716 cells, suggesting that FCP-2-1 could stimulate the secretion of GLP-1 through itself and propionic acid produced by the gut microbiota. These findings indicated that the antidiabetic mechanism of FCP-2-1 might be related to the gut microbiota-GLP-1 pathway.
FCP - 2 - 1是一种从佛手柑中分离纯化得到的水溶性多糖，在我们之前的研究中显示出体外降血糖作用。然而，其在体内的抗糖尿病作用及潜在机制仍有待阐明。在本研究中，我们考察了FCP - 2 - 1对高脂饮食（HFD）和链脲佐菌素（STZ）诱导的糖尿病小鼠的抗糖尿病作用及其对肠道微生物群、短链脂肪酸（SCFAs）和胰高血糖素样肽 - 1（GLP - 1）的影响。结果表明，FCP - 2 - 1可显著减轻糖尿病小鼠的糖尿病症状，恢复肠道微生物群的平衡，并增加乙酸和丙酸的含量。特别地，发现FCP - 2 - 1能够促进GLP - 1的分泌，GLP - 1是糖尿病的一个新治疗靶点。此外，丙酸和FCP - 2 - 1能够促进NCI - H716细胞中GLP - 1的分泌，这表明FCP - 2 - 1可能通过自身以及肠道微生物群产生的丙酸来刺激GLP - 1的分泌。这些发现表明，FCP - 2 - 1的抗糖尿病机制可能与肠道微生物群 - GLP - 1途径有关。
