Diep Tram N, Liu Haoxin, Yan Liang-Jun
Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Nutrients. 2025 Feb 22;17(5):772. doi: 10.3390/nu17050772.
The gut microbiota influences and contributes to kidney health and disease. Butyrate, a short-chain fatty acid molecule generated via the fermentation of gut bacterial catabolism of nondigestible dietary fiber, has been shown to exert numerous beneficial effects on kidney disorders. The objective of this review was to discuss the latest findings on the protective effects of butyrate on a variety of animal models of kidney injury. We conducted a PubMed search using the title word "butyrate" and keyword "kidney" to generate our literature review sources. The animal models covered in this review include ischemia-reperfusion renal injury, cisplatin- and folic acid-induced kidney injury, septic kidney injury, diabetic kidney disease (DKD), high-fat diet (HFD)-induced glomerulopathy, adenine-induced chronic kidney disease (CKD), high-salt-induced renal injury, and T-2 toxin-induced kidney injury in birds. The protective mechanisms of butyrate that are most shared among these animal model studies include antioxidative stress, anti-fibrosis, anti-inflammation, and anti-cell death. This review ends with suggestions for future studies on potential approaches that may modulate gut microbiota butyrate production for the well-being of kidneys with the kidney disorders covered in this review.
肠道微生物群会影响肾脏健康并参与其中，同时也会引发肾脏疾病。丁酸盐是一种通过肠道细菌对不可消化膳食纤维进行分解代谢发酵产生的短链脂肪酸分子，已被证明对肾脏疾病具有多种有益作用。本综述的目的是讨论丁酸盐对多种肾脏损伤动物模型保护作用的最新研究结果。我们使用标题词“丁酸盐”和关键词“肾脏”在PubMed上进行搜索，以生成文献综述来源。本综述涵盖的动物模型包括缺血再灌注肾损伤、顺铂和叶酸诱导的肾损伤、脓毒症肾损伤、糖尿病肾病（DKD）、高脂饮食（HFD）诱导的肾小球病、腺嘌呤诱导的慢性肾脏病（CKD）、高盐诱导的肾损伤以及T-2毒素诱导的鸟类肾损伤。这些动物模型研究中最常见的丁酸盐保护机制包括抗氧化应激、抗纤维化、抗炎和抗细胞死亡。本综述最后对未来研究提出了建议，即探讨可能调节肠道微生物群丁酸盐生成的潜在方法，以改善本综述所涵盖的患有肾脏疾病的肾脏健康状况。
