[In vivo activity of drug-metabolizing enzymes in various pathological conditions].

Activity of enzymes, metabolizing drugs, was studied in acute kidney insufficiency and acute purulent peritonitis of rabbits using antipyrine test. In these pathological states the antipyrine half-life was increased and clearance was decreased, thus demonstrating the inhibition of drug-metabolizing enzymes. The data obtained suggest that the antipyrine test may exhibit the rate of drug metabolism in pathological conditions.