Daintith H, Stevenson I H, O'Malley K
Int J Clin Pharmacol Biopharm. 1976 Jan;13(1):55-8.
Drug metabolizing capacity was assessed in 29 normal subjects and in 28 diabetics on various treatment regimes using the rate of antipyrine elimination as reflux. Plasma half-life of antipyrine was markedly shorter (38%), and the plasma clearance of this drug greater (40%) in diabetics receiving insulin than in controls. There was also an indication of a small increase in rate of test drug elimination in diabetics taking chlorpropamide. Patients being controlled solely on diet or those on tolbutamide did not exhibit an altered rate of drug elimination. The rate of metabolism and inactivation of other drugs may be altered in diabetics taking insulin so that optimal doses of some comcomitantly administered drugs may be different in this group of patients.
在29名正常受试者和28名接受不同治疗方案的糖尿病患者中，以安替比林消除速率作为衡量指标评估了药物代谢能力。接受胰岛素治疗的糖尿病患者，其安替比林的血浆半衰期明显缩短（38%），该药物的血浆清除率更高（40%），高于对照组。服用氯磺丙脲的糖尿病患者也有测试药物消除速率略有增加的迹象。仅通过饮食控制的患者或服用甲苯磺丁脲的患者，其药物消除速率未发生改变。服用胰岛素的糖尿病患者，其他药物的代谢和失活速率可能会改变，因此在这组患者中，一些联合使用药物的最佳剂量可能会有所不同。
