Kalacun Vanja, Ekart Robert, Bevc Sebastjan, Skok Pavel, Hojs Radovan, Vodošek Hojs Nina
Department of Gastroenterology, Clinic for Internal Medicine, University Medical Centre Maribor, Maribor, Slovenia.
Department of Dialysis, Clinic for Internal Medicine, University Medical Centre Maribor, Maribor, Slovenia.
Ren Fail. 2025 Dec;47(1):2455523. doi: 10.1080/0886022X.2025.2455523. Epub 2025 Jan 22.
Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease are global public health issues associated with high morbidity and mortality. Both diseases are also interlinked. Little is known about the meaning of NAFLD in hemodialysis (HD) patients. Therefore, the aim of our study was to investigate the difference in oxidative stress and inflammation in HD patients with or without advanced NAFLD. Seventy-seven HD patients were included (65.14 ± 12.34 years, 59.2% male) and divided according to abdominal ultrasound and two-dimensional shear wave elastography (2D-SWE) measurements into two groups: 1) no NAFLD or no advanced NAFLD (2D-SWE <9 kPa) and 2) advanced NAFLD (2D-SWE ≥9 kPa). Medical history data and blood results were collected. HD patients with advanced NAFLD had significantly higher levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG; = 0.025), tumor necrosis factor-alpha (TNF-α; = 0.023), and intercellular adhesion molecule 1 (ICAM-1; = 0.015) in comparison to HD patients without advanced NAFLD. Interleukin 6 (IL-6) was higher in the advanced NAFLD group, but the difference was of borderline significance ( = 0.054). There was no significant difference in high-sensitivity C-reactive protein (hs-CRP), and vascular cell adhesion molecule 1 (VCAM-1) between groups. In binary logistic regression analysis, advanced NAFLD was significantly associated with 8-OHdG and ICAM-1. In conclusion, higher oxidative stress and inflammation levels are present in HD patients with advanced NAFLD.
非酒精性脂肪性肝病（NAFLD）和慢性肾脏病是全球性的公共卫生问题，发病率和死亡率都很高。这两种疾病也相互关联。关于NAFLD在血液透析（HD）患者中的意义，人们了解甚少。因此，我们研究的目的是调查有无晚期NAFLD的HD患者在氧化应激和炎症方面的差异。纳入了77例HD患者（年龄65.14±12.34岁，男性占59.2%），并根据腹部超声和二维剪切波弹性成像（2D-SWE）测量结果将其分为两组：1）无NAFLD或无晚期NAFLD（2D-SWE<9kPa）和2）晚期NAFLD（2D-SWE≥9kPa）。收集了病史数据和血液检查结果。与无晚期NAFLD的HD患者相比，晚期NAFLD的HD患者8-羟基-2'-脱氧鸟苷（8-OHdG；P=0.025）、肿瘤坏死因子-α（TNF-α；P=0.023）和细胞间黏附分子1（ICAM-1；P=0.015）水平显著更高。晚期NAFLD组白细胞介素6（IL-6）更高，但差异具有临界显著性（P=0.054）。两组之间高敏C反应蛋白（hs-CRP）和血管细胞黏附分子1（VCAM-1）无显著差异。在二元逻辑回归分析中，晚期NAFLD与8-OHdG和ICAM-1显著相关。总之，晚期NAFLD的HD患者存在更高的氧化应激和炎症水平。
