Yang Xusheng
Department of Nephrology, Beijing Rehabilitation Hospital, Affiliated to Capital Medical University, Beijing, China.
Ren Fail. 2025 Dec;47(1):2454970. doi: 10.1080/0886022X.2025.2454970. Epub 2025 Jan 22.
This cross-sectional study aimed to investigate the association between drinking patterns and prevalence of diabetic kidney disease (DKD) among adults in the United States.
Data were analyzed from the NHANES surveys conducted between 1999 and 2016, including 26,473 participants. Drinking patterns were categorized by frequency (weekly, monthly, or yearly) and quantity (light, moderate, or heavy, based on daily consumption). Among participants with diabetes, DKD was defined using the albumin-to-creatinine ratio (ACR ≥30 mg/g) and estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m). Multivariable logistic regression models were used to evaluate associations, adjusting for potential confounders across the four models. Subgroup analyses were performed to assess the effects of modification by age, sex, race, BMI.
Drinking patterns and DKD were analyzed among 26,473 US adults (mean age, 46.6 years; 53.7% male). After adjusting for multiple confounders, heavy alcohol consumption was associated with a higher risk of DKD than light drinking (OR = 1.23, 95% CI, 1.04-1.46; = 0.016). Conversely, moderate drinking frequency (3-4 days per week, 2-5 days per month, 3-126 days per year) was associated with a reduced DKD risk (OR = 0.67, 95% CI, 0.49-0.91; OR = 0.75, 95% CI, 0.56-0.99, OR = 0.71, 95% CI, 0.58-0.86, respectively). A nonlinear association was observed between alcohol consumption frequency and DKD in terms of weekly and yearly drinking days.
This study highlights the importance of drinking behavior in the management of diabetic kidney disease. Daily alcohol consumption was associated with an increased risk of DKD, whereas moderate alcohol consumption was associated with a reduced risk. These findings suggest that moderate drinking frequency may not exacerbate renal burden in individuals with diabetes and provide new perspectives for clinical interventions.
本横断面研究旨在调查美国成年人饮酒模式与糖尿病肾病（DKD）患病率之间的关联。
分析了1999年至2016年间进行的美国国家健康与营养检查调查（NHANES）的数据，包括26473名参与者。饮酒模式按频率（每周、每月或每年）和饮酒量（根据每日饮酒量分为轻度、中度或重度）进行分类。在患有糖尿病的参与者中，DKD通过白蛋白与肌酐比值（ACR≥30mg/g）和估计肾小球滤过率（eGFR<60mL/min/1.73m²）来定义。使用多变量逻辑回归模型评估关联，并在四个模型中对潜在混杂因素进行调整。进行亚组分析以评估年龄、性别、种族、体重指数（BMI）的修正效应。
对26473名美国成年人（平均年龄46.6岁；53.7%为男性）的饮酒模式和DKD进行了分析。在调整了多个混杂因素后，重度饮酒与DKD风险高于轻度饮酒相关（OR=1.23，95%CI为1.04-1.46；P=0.016）。相反，适度饮酒频率（每周3-4天、每月2-5天、每年3-126天）与DKD风险降低相关（OR分别为0.67，95%CI为0.49-0.91；OR为0.75，95%CI为0.56-0.99；OR为0.71，95%CI为0.58-0.86）。在每周和每年饮酒天数方面，观察到饮酒频率与DKD之间存在非线性关联。
本研究强调了饮酒行为在糖尿病肾病管理中的重要性。每日饮酒与DKD风险增加相关，而适度饮酒与风险降低相关。这些发现表明，适度饮酒频率可能不会加重糖尿病患者的肾脏负担，并为临床干预提供了新的视角。
