Kachaner Alexandra, Seror Raphaele, Le Guern Véronique, Dieudé Philippe, Gottenberg Jacques-Eric, Hachulla Eric, Devauchelle-Pensec Valérie, Perdriger Aleth, Dernis Emanuelle, Couderc Marion, Berville Sophie, Mariette Xavier, Belkhir Rakiba, Nocturne Gaetane
Hospital Bicetre, Le Kremlin-Bicetre, France
Rheumatology, Hôpitaux universitaires Paris-Sud, Le Kremlin Bicêtre, France.
RMD Open. 2025 Jan 21;11(1):e004693. doi: 10.1136/rmdopen-2024-004693.
This study aimed to assess the impact of Sjögren disease (SjD) on the quality of sexual life and its determinants using the Qualisex questionnaire.
The Qualisex questionnaire was administered to participants within the ASSESS cohort, a French national multicentric prospective cohort of individuals with SjD. Patients' characteristics and psychometric evaluations were also collected.
Among the 395 patients of the cohort, 92 (23%) completed the questionnaire, with a median age of 56 (44-59) years and a female ratio of 92% (85/92). The median Qualisex score was 3.4 (1.1-5.9).Comparing the first and last quartiles of the Qualisex score, a worst sexual satisfaction was associated with older age (median (IQR) 58 (52-65) vs 52 (41-56) years, p=0.005), higher EULAR Sjögren's disease Patient Reported Index (ESSPRI) (6.8 (5.7-7.7) vs 4.3 (2.8-5.3), p<0.0001) lower SF-36 mental and physical scores (respectively, 43 (38-46) vs 49 (47-53), p=0.0035 and 31 (29-35) vs 35 (30-37), p=0.035), higher Depression and Anxiety scores (HADS) (respectively, 9 (7-11) vs 2 (1-4), p<0.0001 and 11 (8-14) vs 7 (4-10), p=0.006). Interestingly, EULAR Sjögren's disease Disease Activity Index (ESSDAI) score did not differ significantly (4 (1-10) vs 2.5 (1.8-4), p=0.35). In a multivariable analysis, the Qualisex score remained strongly associated with a higher HADS depression score and, to a lesser extent, with a higher ESSPRI. The inability to obtain a score was associated with older age.
In SjD patients, sexual satisfaction assessed with the Qualisex score, was strongly associated with depression and, to lesser extent, with ESSPRI, but not with systemic activity.
本研究旨在使用Qualisex问卷评估干燥综合征（SjD）对性生活质量的影响及其决定因素。
对法国全国多中心前瞻性干燥综合征患者队列ASSESS中的参与者进行Qualisex问卷调查。还收集了患者的特征和心理测量评估结果。
在该队列的395名患者中，92名（23%）完成了问卷，中位年龄为56（44 - 59）岁，女性比例为92%（85/92）。Qualisex评分中位数为3.4（1.1 - 5.9）。比较Qualisex评分的第一个和最后一个四分位数，较差的性满意度与年龄较大相关（中位数（四分位间距）58（52 - 65）岁对52（41 - 56）岁，p = 0.005）、较高的欧洲抗风湿病联盟干燥综合征患者报告指数（ESSPRI）（6.8（5.7 - 7.7）对4.3（2.8 - 5.3），p < 0.0001）、较低的SF - 36精神和身体评分（分别为43（38 - 46）对49（47 - 53），p = 0.0035和31（29 - 35）对35（30 - 37），p = 0.035）、较高的抑郁和焦虑评分（医院焦虑抑郁量表（HADS））（分别为9（7 - 11）对2（1 - 4），p < 0.0001和11（8 - 14）对7（4 - 10），p = 0.006）。有趣的是，欧洲抗风湿病联盟干燥综合征疾病活动指数（ESSDAI）评分无显著差异（4（1 - 10）对2.5（1.8 - 4），p = 0.35）。在多变量分析中，Qualisex评分仍与较高的HADS抑郁评分密切相关，在较小程度上与较高的ESSPRI相关。无法获得评分与年龄较大相关。
在干燥综合征患者中，用Qualisex评分评估的性满意度与抑郁密切相关，在较小程度上与ESSPRI相关，但与全身活动无关。
