原发性干燥综合征患者的人格、抑郁和焦虑状况——与社会人口学因素和共病的关联。
Personality, depression and anxiety in primary Sjogren's syndrome - Association with sociodemographic factors and comorbidity.
机构信息
Department of Rheumatology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Department of Psychiatry, Clinical Centre of Serbia, Belgrade, Serbia.
出版信息
PLoS One. 2019 Jan 17;14(1):e0210466. doi: 10.1371/journal.pone.0210466. eCollection 2019.
OBJECTIVE
Patients with primary Sjögren's Syndrome (pSS) have diminished health quality and fatigue, arthralgia along with dryness of the mouth and eyes have major impact on their psychological and social aspects of life. The purpose of this study was to determine psychological features of patients with pSS. We analyzed personality, depression and anxiety of patients with primary Sjögren's Syndrome (pSS) in comparison with patients with rheumatoid arthritis (RA) and healthy controls (HC) and assessed their association with sociodemographic factors and comorbidity.
METHODS
In 105 pSS patients (mean age 51.34 years, mean disease duration 5.98 years), 52 RA patients (mean age 51.37 years, mean disease duration 8.10 years) and 54 HC (mean age 51.35 years) clinical and sociodemographic characteristics were determined and results analyzed. At enrollment patients and controls completed the Revisited NEO Personality Inventory Five-Factor model (NEO-PI-R), the Zung Self-Rating Depression Scale and the Zung Self-Rating Anxiety Scale. Statistical analyses were performed using SPSS [Version 16.0]. The relative size of the effect was assessed based on standardized estimates of effect size (d).
RESULTS
Patients with pSS, similarly to RA patients had higher scores of Neuroticism (d = 0.46, p = 0.007) and lower scores of Extraversion (d = 0.51, p = 0.001) and Openness for experience (d = 0.65, p = 0.013) compared to HC. There was no significant differences between pSS group and HC in the depression (d = 0.171, p>0.05). However, patients with pSS had higher anxiety in comparison to HC (p<0.0001). In multivariate models, education and satisfaction with family relationships were significant predictors for psychological characteristics of patients, independently of clinical diagnosis.
CONCLUSIONS
Our study is the first to show that patients with pSS scored high on neuroticism and anxiety and low on sociability. Education and satisfaction with family relationships predisposed to their psychological profile. Psychological assessment of patients with pSS may improve understanding and treatment of this clinical condition.
目的
原发性干燥综合征（pSS）患者的健康质量下降，伴有疲劳、关节痛以及口干和眼干，这对他们的心理和社会生活方面有重大影响。本研究的目的是确定 pSS 患者的心理特征。我们分析了原发性干燥综合征（pSS）患者的人格、抑郁和焦虑，并与类风湿关节炎（RA）患者和健康对照（HC）进行了比较，并评估了它们与社会人口因素和合并症的关系。
方法
在 105 例 pSS 患者（平均年龄 51.34 岁，平均病程 5.98 年）、52 例 RA 患者（平均年龄 51.37 岁，平均病程 8.10 年）和 54 例 HC（平均年龄 51.35 岁）中，确定了临床和社会人口学特征，并进行了分析。入组时，患者和对照者完成了修订后的 NEO 人格量表五因素模型（NEO-PI-R）、Zung 自评抑郁量表和 Zung 自评焦虑量表。使用 SPSS [版本 16.0]进行统计分析。采用标准化效应大小（d）评估效应的相对大小。
结果
pSS 患者与 RA 患者一样，神经质得分较高（d = 0.46，p = 0.007），外向性得分较低（d = 0.51，p = 0.001）和开放性经验得分较低（d = 0.65，p = 0.013）与 HC 相比。pSS 组与 HC 组在抑郁方面无显著差异（d = 0.171，p>0.05）。然而，与 HC 相比，pSS 患者的焦虑程度更高（p<0.0001）。在多变量模型中，教育和对家庭关系的满意度是患者心理特征的独立预测因素，与临床诊断无关。
结论
我们的研究首次表明，pSS 患者的神经质和焦虑程度较高，社交能力较低。教育和对家庭关系的满意度决定了他们的心理特征。对 pSS 患者进行心理评估可以提高对这种临床情况的理解和治疗。
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