Rubnitz Zach, Nevala-Plagemann Chris, Florou Vaia, Garrido-Laguna Ignacio
Internal Medicine, University of Utah Health, Salt Lake City, Utah, USA
Medical Oncology, Huntsman Cancer Institute Cancer Hospital, Salt Lake City, Utah, USA.
BMJ Case Rep. 2025 Jan 21;18(1):e259660. doi: 10.1136/bcr-2024-259660.
Gemcitabine, a cytosine analogue, is a cytotoxic agent commonly used in the treatment of patients with a variety of solid tumours, including non-small cell lung cancer, cholangiocarcinoma and breast, pancreatic, testicular and ovarian cancers. Although generally well-tolerated, several reports suggest that it can rarely cause myositis. We present a case of gemcitabine-induced myositis in a patient with pancreatic adenocarcinoma and review the literature on this topic.
吉西他滨是一种胞嘧啶类似物，是一种细胞毒性药物，常用于治疗多种实体瘤患者，包括非小细胞肺癌、胆管癌以及乳腺癌、胰腺癌、睾丸癌和卵巢癌。尽管吉西他滨通常耐受性良好，但有几份报告表明它很少会引起肌炎。我们报告一例胰腺腺癌患者发生吉西他滨诱导的肌炎病例，并对该主题的文献进行综述。
