Barrios-Anderson Adriel, Radhakrishnan Reshmitha, Yu Esther, Shimanovsky Alexei
The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
BMJ Case Rep. 2021 May 4;14(5):e240896. doi: 10.1136/bcr-2020-240896.
Radiation recall (RR) is a chemotherapy-induced reaction that leads to inflammation and necrosis in previously irradiated tissue. Gemcitabine is a cytidine analogue that is often used in conjunction with nab-paclitaxel in the treatment of pancreatic cancer. Herein, we present a case of a 56-year-old woman with stage III pancreatic adenocarcinoma diagnosed with gemcitabine-induced RR when she presented with lower back pain and new rim-enhancing collections within the right and left paraspinal musculature 5 months after radiation therapy to the pancreas. A PubMed search was performed for 'Radiation Recall Myositis' and a complete literature review performed. This case and review of the literature of published cases of RR myositis highlight the clinical course and presentation of RR myositis. This review highlights the importance of considering RR in the differential diagnosis when patients who are undergoing chemotherapy and radiation present with inflammatory changes in previously irradiated areas.
放射性回忆反应（RR）是一种化疗诱导的反应，可导致先前接受过放射治疗的组织发生炎症和坏死。吉西他滨是一种胞苷类似物，常用于联合纳米白蛋白结合型紫杉醇治疗胰腺癌。在此，我们报告一例56岁的III期胰腺腺癌女性患者，在胰腺接受放射治疗5个月后，出现下背部疼痛，且左右椎旁肌肉组织内有新的边缘强化灶，被诊断为吉西他滨诱导的RR。我们在PubMed上搜索了“放射性回忆性肌炎”，并进行了全面的文献综述。该病例以及已发表的RR性肌炎病例的文献综述突出了RR性肌炎的临床病程和表现。本综述强调，在接受化疗和放疗的患者在先前照射区域出现炎症变化时，在鉴别诊断中考虑RR的重要性。
