Liu Shuai, Zhan Jiamian, Liu Zhenyu, Tan Xiaoying, Huang Jianxing, Pu Chunyi, Lin Rurong, Chen Yu, Luo Qi, Qiu Xiaozhong, Hou Honghao
The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510900, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Carbohydr Polym. 2025 Mar 15;352:123192. doi: 10.1016/j.carbpol.2024.123192. Epub 2024 Dec 25.
The treatment and monitoring of infected skin wounds present significant clinical challenges. Herein, a multifunctional poly(deep eutectic solvent) (PDES) electroactive hydrogel is developed by optimizing the components and the ratio of hydrogen donors and acceptors, achieving well wound hemostasis, wound healing, and monitoring administration performace. The PDES hydrogel dressing exhibits mechanical properties, including high toughness, fatigue resistance (over 9000 compression cycles), and superior skin adhesion (over 70 kPa). It also demonstrates good conductivity (~2.0 S/m) and a high signal-to-noise ratio (>7000:1), enabling its application as a flexible strain biosensor to monitor wound contraction signals during healing. The PDES hydrogel shows remarkable antibacterial performance (up to 99 %) and blood compatibility, achieving rapid hemostasis (within 15 s) and reducing blood loss (36 mg). Additionally, the PDES hydrogel effectively prevents skin wound infections, enhances collagen deposition, and facilitates microvascular reconstruction at the wound site, significantly improving infected wound healing (in 12 days). Consequently, this PDES hydrogel, with its superior mechanical properties, flexible sensing capabilities, and antibacterial features, is an ideal candidate for wound healing and monitoring administration.
感染性皮肤伤口的治疗和监测面临着重大的临床挑战。在此，通过优化氢供体和受体的成分及比例，开发了一种多功能聚（深共晶溶剂）（PDES）电活性水凝胶，实现了良好的伤口止血、伤口愈合及监测给药性能。PDES水凝胶敷料具有多种机械性能，包括高韧性、抗疲劳性（超过9000次压缩循环）和优异的皮肤粘附性（超过70 kPa）。它还具有良好的导电性（约2.0 S/m）和高信噪比（>7000:1），使其能够作为一种柔性应变生物传感器，在愈合过程中监测伤口收缩信号。PDES水凝胶表现出显著的抗菌性能（高达99%）和血液相容性，实现快速止血（15秒内）并减少失血量（36毫克）。此外，PDES水凝胶能有效预防皮肤伤口感染，增强胶原蛋白沉积，并促进伤口部位的微血管重建，显著改善感染伤口的愈合（12天内）。因此，这种具有优异机械性能、灵活传感能力和抗菌特性的PDES水凝胶，是伤口愈合和监测给药的理想候选材料。
