Jiang Yanhua, Zhou Yongjian, Tian Yu, Nabavi Noushin, Ashrafizadeh Milad, Conde João, Li Zhe, Guo Liang
Department of Anesthesiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Science Research Center, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Mater Today Bio. 2025 Jul 21;34:102114. doi: 10.1016/j.mtbio.2025.102114. eCollection 2025 Oct.
Wound healing, particularly in particularly after surgical operations and especially cardiothoracic surgeries, presents a significant global healthcare burden due to prolonged recovery time, recurrent infections, and limited effectiveness of the conventional therapies. The recent advancements in biomaterials have positioned conductive polymers (CPs) as promising components in the design of next-generation wound care technologies. CPs, such as polypyrrole (PPy), polyaniline (PANI) and poly (3,4-ethylenedioxythiophene) (PEDOT), possess unique electrical, chemical and biological properties, making them ideal for integration into multifunctional and responsive wound dressings. The present review focuses on the emerging role of CPs in wound healing, along with their incorporation into various delivery platforms including hydrogels, nanofibers, membranes, microneedle patches and 3D scaffolds. These materials provide a synergistic approach by enabling localized electrical stimulation, enhancing tissue regeneration, and producing antibacterial, antioxidant and anti-inflammatory effects. In particular, it is discussed how CP-based systems can be engineered to respond dynamically to the wound microenvironment such as pH, temperature or enzymatic activity, for accelerating controlled drug release and real-time therapeutic intervention. It also highlights the integration of CPs with complementary technologies such as triboelectric nanogenerators, biosensors and photothermal agents, contributing to smarter, more personalized wound care solutions. Moreover, this review addresses the current challenges, including biocompatibility, degradation kinetics and scalability, with a summary of the directions for the future research to optimize clinical translation. Based on the recent findings across materials science, bioengineering and regenerative medicine, this review illustrates the transformative potential of CPs in advancing effective, non-invasive and patient-specific wound healing strategies.
伤口愈合，尤其是在外科手术后，特别是心胸外科手术后，由于恢复时间延长、反复感染以及传统疗法效果有限，给全球医疗保健带来了重大负担。生物材料的最新进展使导电聚合物（CPs）成为下一代伤口护理技术设计中有前景的组件。诸如聚吡咯（PPy）、聚苯胺（PANI）和聚（3,4-乙撑二氧噻吩）（PEDOT）等CPs具有独特的电学、化学和生物学特性，使其非常适合集成到多功能和响应性伤口敷料中。本综述重点关注CPs在伤口愈合中的新兴作用，以及它们被纳入各种递送平台，包括水凝胶、纳米纤维、膜、微针贴片和3D支架。这些材料通过实现局部电刺激、促进组织再生以及产生抗菌、抗氧化和抗炎作用，提供了一种协同方法。特别是，讨论了如何设计基于CP的系统以动态响应伤口微环境，如pH值、温度或酶活性，以加速可控药物释放和实时治疗干预。它还强调了CPs与摩擦电纳米发电机、生物传感器和光热剂等互补技术的整合，有助于实现更智能、更个性化的伤口护理解决方案。此外，本综述探讨了当前的挑战，包括生物相容性、降解动力学和可扩展性，并总结了未来研究的方向，以优化临床转化。基于材料科学、生物工程和再生医学的最新发现，本综述阐述了CPs在推进有效、非侵入性和针对患者的伤口愈合策略方面的变革潜力。
