Xiong Zhencheng, Lin Bingqing, Huang Cheng, Duan Ao, Zhang Chaoyi, Qiang Guangliang, Liu Wenzheng, Zhao Renliang, Deng Xiangtian, Wang Dong, Ge Zilu, Wang Guanglin, Hu Xiaoran, Lin Wei
Department of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China; Trauma Medical Center, West China Hospital, Sichuan University, Chengdu 610041, China; Med-X Center for Manufacturing Sichuan University, Chengdu 610041, China.
School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 611731, China.
Carbohydr Polym. 2025 Mar 15;352:123149. doi: 10.1016/j.carbpol.2024.123149. Epub 2024 Dec 13.
Achilles tendon rupture is a common and serious condition that remains a challenge in the restoration of tendon structure and function. The design and use of high-performance piezoelectric materials serve as an effective solution to enhance repair outcomes, shorten recovery times, and reduce the risk of recurrence. In this study, we prepared a chitosan piezoelectric gel (CSPG) as an organic polymer with excellent biocompatibility, stretchability, and piezoelectric properties as well as excellent antibacterial properties. In vitro experiments showed that CSPG, which induces a piezoelectric effect, can inhibit bacterial growth, promote cell proliferation and migration, upregulate the expression of tendon-related genes, and inhibit the expression of inflammation-related genes. In vivo experiments showed improved outcomes for Achilles tendon repair following CSPG intervention, as evidenced by enhanced animal mobility and improved mechanical test results. In addition, the CSPG exhibited sensory functions capable of monitoring temperature and motion, providing timely feedback on repair efficacy. In summary, this study not only successfully prepared a multifunctional piezoelectric material that can effectively promote Achilles tendon rupture repair and regeneration and control inflammatory response, it also possesses antibacterial and sensing functions, thus offering a new strategy for Achilles tendon rupture repair.
跟腱断裂是一种常见且严重的病症，在肌腱结构和功能的恢复方面仍然是一项挑战。高性能压电材料的设计和应用是提高修复效果、缩短恢复时间并降低复发风险的有效解决方案。在本研究中，我们制备了一种壳聚糖压电凝胶（CSPG），它作为一种有机聚合物，具有优异的生物相容性、拉伸性、压电性能以及出色的抗菌性能。体外实验表明，能产生压电效应的CSPG可抑制细菌生长、促进细胞增殖和迁移、上调肌腱相关基因的表达并抑制炎症相关基因的表达。体内实验显示，CSPG干预后跟腱修复效果得到改善，动物活动能力增强以及力学测试结果改善证明了这一点。此外，CSPG具有监测温度和运动的传感功能，能及时反馈修复效果。总之，本研究不仅成功制备了一种多功能压电材料，可有效促进跟腱断裂的修复和再生并控制炎症反应，还具备抗菌和传感功能，从而为跟腱断裂修复提供了一种新策略。
