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Tol-Pal系统整合了三层细胞包膜的维持功能。

The Tol Pal system integrates maintenance of the three layered cell envelope.

作者信息

Szczepaniak Joanna, Webby Melissa N

机构信息

Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK.

出版信息

NPJ Antimicrob Resist. 2024 Dec 5;2(1):46. doi: 10.1038/s44259-024-00065-0.

DOI:10.1038/s44259-024-00065-0
PMID:39843782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11721397/
Abstract

The rapid emergence of antibiotic-resistant superbugs poses a significant global health threat. Gram-negative bacteria are the primary culprits due to their robust, tripartite cell envelope. This review explores the emerging role of the trans-envelope Tol-Pal system in maintaining envelope integrity, by connecting envelope layers and serving as a protein interaction hub. Targeting the Tol-Pal system offers a promising approach for the development of novel envelope-disrupting antimicrobials.

摘要

抗生素耐药超级细菌的迅速出现对全球健康构成了重大威胁。革兰氏阴性菌因其坚固的三层细胞膜而成为主要罪魁祸首。本综述探讨了跨膜Tol-Pal系统在维持细胞膜完整性方面新出现的作用，该系统通过连接细胞膜各层并作为蛋白质相互作用中心来发挥作用。针对Tol-Pal系统为开发新型破坏细胞膜的抗菌药物提供了一种有前景的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/d5f8a476be9b/44259_2024_65_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/2eb81ae8680d/44259_2024_65_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/758a255df5c3/44259_2024_65_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/06399bf599c7/44259_2024_65_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/e54b6e322e76/44259_2024_65_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/d5f8a476be9b/44259_2024_65_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/2eb81ae8680d/44259_2024_65_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/758a255df5c3/44259_2024_65_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/06399bf599c7/44259_2024_65_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/e54b6e322e76/44259_2024_65_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2346/11721397/d5f8a476be9b/44259_2024_65_Fig5_HTML.jpg

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Nat Commun. 2024 Sep 2;15(1):7616. doi: 10.1038/s41467-024-51790-z.
2
Co-ordinated assembly of the multilayered cell envelope of Gram-negative bacteria.革兰氏阴性细菌多层细胞包膜的协调组装。
Curr Opin Microbiol. 2024 Jun;79:102479. doi: 10.1016/j.mib.2024.102479. Epub 2024 May 7.
3
Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.
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Nat Commun. 2024 Jan 6;15(1):331. doi: 10.1038/s41467-023-44606-z.
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SlyB encapsulates outer membrane proteins in stress-induced lipid nanodomains.SlyB将外膜蛋白包裹在应激诱导的脂质纳米结构域中。
Nature. 2024 Feb;626(7999):617-625. doi: 10.1038/s41586-023-06925-5. Epub 2023 Dec 11.
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Tunable force transduction through the cell envelope.通过细胞膜实现可调的力转导。
Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2306707120. doi: 10.1073/pnas.2306707120. Epub 2023 Nov 16.
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The Gram-negative permeability barrier: tipping the balance of the in and the out.革兰氏阴性通透性屏障：颠覆内外平衡。
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A role for the Gram-negative outer membrane in bacterial shape determination.革兰氏阴性外膜在细菌形状决定中的作用。
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