Soler Wenglein Janina, Simon Arne, Berner Reinhard, Brockmeyer Holger, Forster Johannes, Hamelmann Eckard, Klein Wolfgang, Liese Johannes, Neubert Jennifer, Pfeil Johannes, Renk Hanna, Tenenbaum Tobias, Toepfner Nicole, Hufnagel Markus, Tillmann Roland
Department of Pediatrics, Protestant Hospital of the Bethel Foundation, Medical School and University Medical Center OWL, Bielefeld University, Bielefeld, Germany.
Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Science (ZBAF), Department of Human Medicine, Faculty of Medicine, Witten/Herdecke University, Witten, Germany.
Eur J Pediatr. 2025 Jan 23;184(2):149. doi: 10.1007/s00431-024-05964-y.
In pediatric outpatient care, overuse and misuse of antibiotics is linked to a high risk of adverse events and increased antibiotic resistance. In 2019, building upon the work of the Antibiotic Therapy in Bielefeld (AnTiB) project (founded in 2016), a collaboration among the AnTiB, the German Society for Pediatric Infectious Diseases (DGPI), and the Professional Association of Outpatient Pediatricians and Adolescent Physicians (BVKJ) was established to develop consensus recommendations for antibiotic therapy in pediatric outpatient settings in Germany. This working group became the Antibiotic Stewardship in Outpatient Pediatrics (ABSaP). ABSaP institutes recommendations for antibiotic use in outpatient pediatric settings in Germany and updates them regularly. The ABSaP guidelines recommend restrictive, targeted, evidence-based prescription practices for antibiotics used to treat common infections among pediatric outpatients. This expert-driven, pragmatic, best-practice guidance is designed to be a living document. ABSaP's most recent update was published in March 2024. The recommendations aim to guide and standardize rational antibiotics use by emphasizing the importance of avoiding unnecessary prescriptions, while also promoting the application of narrow-spectrum antibiotics, short-duration therapy, and watchful waiting, when treating mild, self-limiting infections in children without significant risk factors.
ABSaP's guidelines may provide a model for others, as well as offer a basis for discussing practical, effective antibiotic stewardship (ABS) measures in pediatric primary care. An international, expert consensus on ABS for pediatric outpatients could help promote a culture of responsible antibiotic use, improve prescribing safety, and contribute to broader ABS efforts.
• Overuse and misuse of antibiotics are associated with adverse events and increased antibiotic resistance, prompting the need for effective antibiotic stewardship initiatives. • The Antibiotic Stewardship in Outpatient Pediatrics (ABSaP) working group was established to develop and regularly update evidence-based best practice recommendations for the targeted and restrictive use of antibiotics in pediatric outpatient settings in Germany.
• The most recent update of the ABSaP guidelines was published in March 2024, emphasizing the importance of narrow-spectrum antibiotics, short-duration therapy, and watchful waiting for mild infections, aiming to standardize rational antibiotic use in children. • The ABSaP guidelines have become widely accepted in Germany and are now being translated into English to foster international dialogue and collaboration on antibiotic stewardship in pediatric primary care, potentially serving as a model for similar initiatives in other countries.
在儿科门诊护理中，抗生素的过度使用和误用与不良事件的高风险以及抗生素耐药性增加有关。2019年，在比勒费尔德抗生素治疗项目（AnTiB，成立于2016年）的基础上，AnTiB、德国儿科传染病学会（DGPI）和门诊儿科医生及青少年医生专业协会（BVKJ）开展合作，为德国儿科门诊环境中的抗生素治疗制定共识性建议。这个工作组成为了儿科门诊抗生素管理（ABSaP）。ABSaP制定德国儿科门诊环境中抗生素使用的建议并定期更新。ABSaP指南建议对用于治疗儿科门诊常见感染的抗生素采取限制性、针对性、循证处方做法。这种由专家驱动、务实的最佳实践指南旨在成为一份动态文件。ABSaP的最新更新于2024年3月发布。这些建议旨在通过强调避免不必要处方的重要性来指导和规范合理使用抗生素，同时在治疗无重大风险因素的儿童轻度自限性感染时，也提倡使用窄谱抗生素、短疗程治疗和观察等待。
ABSaP指南可能为其他指南提供范例，也为讨论儿科初级护理中切实有效的抗生素管理（ABS）措施提供基础。关于儿科门诊抗生素管理的国际专家共识有助于促进负责任使用抗生素的文化，提高处方安全性，并为更广泛的抗生素管理努力做出贡献。
• 抗生素的过度使用和误用与不良事件及抗生素耐药性增加相关，这促使需要有效的抗生素管理举措。• 成立了儿科门诊抗生素管理（ABSaP）工作组，以制定并定期更新关于德国儿科门诊环境中针对性和限制性使用抗生素的循证最佳实践建议。
• ABSaP指南的最新更新于2024年3月发布，强调窄谱抗生素、短疗程治疗和对轻度感染进行观察等待的重要性，旨在规范儿童合理使用抗生素。• ABSaP指南在德国已被广泛接受，目前正在翻译成英文，以促进儿科初级护理中抗生素管理方面的国际对话与合作，可能成为其他国家类似举措的范例。
