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Discovering and targeting mitochondrial loss in NOTCH1-related aortic aneurysm.

出版信息

Nat Cardiovasc Res. 2025 Feb;4(2):129-130. doi: 10.1038/s44161-025-00607-3.

DOI:10.1038/s44161-025-00607-3
PMID:39843802
Abstract
摘要

相似文献

1
Discovering and targeting mitochondrial loss in NOTCH1-related aortic aneurysm.发现并靶向Notch1相关主动脉瘤中的线粒体丢失
Nat Cardiovasc Res. 2025 Feb;4(2):129-130. doi: 10.1038/s44161-025-00607-3.
2
Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease.主动脉平滑肌芯片揭示二叶式主动脉瓣疾病主动脉瘤中线粒体动力学受损可作为治疗靶点。
Elife. 2021 Sep 6;10:e69310. doi: 10.7554/eLife.69310.
3
Correcting mitochondrial loss mitigates NOTCH1-related aortopathy in mice.纠正线粒体缺失可减轻小鼠中与NOTCH1相关的主动脉病变。
Nat Cardiovasc Res. 2025 Feb;4(2):235-247. doi: 10.1038/s44161-024-00603-z. Epub 2025 Jan 14.
4
Genotype-phenotype correlation in patients with bicuspid aortic valve and aneurysm.二叶式主动脉瓣和动脉瘤患者的基因型-表型相关性。
J Thorac Cardiovasc Surg. 2013 Jul;146(1):158-165.e1. doi: 10.1016/j.jtcvs.2012.09.060. Epub 2012 Oct 23.
5
Novel loss of function mutation in NOTCH1 in a family with bicuspid aortic valve, ventricular septal defect, thoracic aortic aneurysm, and aortic valve stenosis.一个家系中存在二叶式主动脉瓣、室间隔缺损、胸主动脉瘤和主动脉瓣狭窄，NOTCH1 中存在新的功能丧失突变。
Mol Genet Genomic Med. 2020 Oct;8(10):e1437. doi: 10.1002/mgg3.1437. Epub 2020 Jul 27.
6
Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.Notch1 杂合性缺失导致小鼠升主动脉瘤。
JCI Insight. 2017 Nov 2;2(21):91353. doi: 10.1172/jci.insight.91353.
7
Gene as a Novel Cause of Thoracic Aortic Aneurysm in Patients with Tricuspid Aortic Valve: Two Cases Reported.基因是三尖瓣主动脉瓣患者胸主动脉瘤的新病因：两例报告。
Int J Mol Sci. 2023 May 12;24(10):8644. doi: 10.3390/ijms24108644.
8
Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms.二叶式主动脉瓣疾病和胸主动脉瘤患者中的新型NOTCH1突变
J Thorac Cardiovasc Surg. 2007 Aug;134(2):290-6. doi: 10.1016/j.jtcvs.2007.02.041.
9
Effect of endovascular therapy on the expression levels of serum T lymphocyte subsets, Notch1 and TACE proteins in patients with abdominal aortic aneurysm.血管内治疗对腹主动脉瘤患者血清T淋巴细胞亚群、Notch1和肿瘤坏死因子-α转换酶蛋白表达水平的影响
Am J Transl Res. 2021 Mar 15;13(3):1808-1816. eCollection 2021.
10
Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm.二叶式主动脉瓣患者伴或不伴升主动脉瘤时 Notch1 通路失调与循环内皮祖细胞（EPC）数量的变化
Sci Rep. 2018 Sep 14;8(1):13834. doi: 10.1038/s41598-018-32170-2.

本文引用的文献

1
Mechanisms of Aortic Dilation in Patients With Bicuspid Aortic Valve: JACC State-of-the-Art Review.二叶式主动脉瓣患者主动脉扩张的机制：美国心脏病学会现状评论。
J Am Coll Cardiol. 2023 Aug 1;82(5):448-464. doi: 10.1016/j.jacc.2022.10.042.
2
Gene as a Novel Cause of Thoracic Aortic Aneurysm in Patients with Tricuspid Aortic Valve: Two Cases Reported.基因是三尖瓣主动脉瓣患者胸主动脉瘤的新病因：两例报告。
Int J Mol Sci. 2023 May 12;24(10):8644. doi: 10.3390/ijms24108644.
3
Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm.
患者来源的微生理模型鉴定二甲双胍治疗胸主动脉瘤的潜力。
EBioMedicine. 2022 Jul;81:104080. doi: 10.1016/j.ebiom.2022.104080. Epub 2022 May 27.
4
Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.Notch1 杂合性缺失导致小鼠升主动脉瘤。
JCI Insight. 2017 Nov 2;2(21):91353. doi: 10.1172/jci.insight.91353.
5
Mutations in NOTCH1 cause aortic valve disease.NOTCH1基因的突变会导致主动脉瓣疾病。
Nature. 2005 Sep 8;437(7056):270-4. doi: 10.1038/nature03940. Epub 2005 Jul 17.