Kawata Daisuke, Ueno Hiroshi M, Nakano Ayatake, Tatara Yota, Tamada Yoshinori, Mikami Tatsuya, Murashita Koichi, Nakaji Shigeyuki, Itoh Ken
Department of Precision Nutrition for Dairy Foods, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Milk Science Research Institute, Megmilk Snow Brand Co., Ltd., Kawagoe, Japan.
Hypertens Res. 2025 Apr;48(4):1409-1421. doi: 10.1038/s41440-024-02088-6. Epub 2025 Jan 22.
The prevalence of hypertension in Japan remains high, owing to the high salt content of the typical Japanese diet. Dairy-based foods may reduce blood pressure and hypertension risk. However, dairy consumption is low in Japan, and the relationships between dairy intake and blood pressure or the mechanisms by which dairy products affect blood pressure are not fully understood. This cross-sectional study was conducted as part of the Iwaki Health Promotion Project in Aomori, Japan. A total of 1071 participants were included from those who underwent annual medical checkups in June 2015. Adjusted multivariate linear and logistic regression analyses were performed to analyze the relationships between dairy consumption and blood pressure or hypertension risk. Comprehensive blood biomarker measurements were also performed. Whole- and high-fat dairy consumption was found to have significant inverse associations with systolic blood pressure (SBP) for all participants (β = -0.0213, P = 0.044) and with SBP and systolic hypertension risk for non-users of antihypertensive medicines (β = -0.0306, P = 0.011; and OR = 0.9927, P = 0.016; respectively). Three blood biomarkers related to phosphorus metabolism (inorganic phosphorus, intact parathyroid hormone, and interleukin-6) were associated with both dairy consumption and SBP. Dairy consumption had a partial inverse association with SBP and hypertension risk in a Japanese population with high salt and low dairy consumption. Analysis of blood biomarkers suggested that phosphorus metabolism is involved in the associations between dairy consumption and blood pressure.
由于典型的日本饮食中盐分含量高，日本高血压的患病率仍然很高。以乳制品为基础的食物可能会降低血压和患高血压的风险。然而，日本的乳制品消费量较低，乳制品摄入量与血压之间的关系或乳制品影响血压的机制尚未完全明确。这项横断面研究是作为日本青森县磐城健康促进项目的一部分进行的。共有1071名参与者来自于2015年6月接受年度体检的人群。进行了调整后的多变量线性和逻辑回归分析，以分析乳制品消费与血压或高血压风险之间的关系。还进行了全面的血液生物标志物测量。结果发现，全脂和高脂乳制品消费与所有参与者的收缩压（SBP）呈显著负相关（β = -0.0213，P = 0.044），与未使用抗高血压药物者的SBP和收缩期高血压风险呈负相关（β = -0.0306，P = 0.011；OR = 0.9927，P = 0.016）。三种与磷代谢相关的血液生物标志物（无机磷、完整甲状旁腺激素和白细胞介素-6）与乳制品消费和SBP均相关。在盐摄入量高且乳制品消费量低的日本人群中，乳制品消费与SBP和高血压风险呈部分负相关。血液生物标志物分析表明，磷代谢参与了乳制品消费与血压之间的关联。
