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Mechanism of engineered macrophage membrane bionic gene-carrying nanospheres for targeted drug delivery to promote wound repair in deep second-degree burns.

作者信息

Zhu Zhihan, Zhu Xinghua, Miao Shichen, Wang Bolin, Li Zihan, Zhang Dinghao, Zou Shentian, Zhang Yi, Zhang Qingrong, Hu Kesu

机构信息

Department of Burn and Plastic Surgery, Medical School of Nantong University, Nantong, 226000, Jiangsu, China.

Department of Burn and Plastic Surgery, The First People's Hospital of Changzhou, Jiangsu, 213000, China.

出版信息

Sci Rep. 2025 Jan 22;15(1):2756. doi: 10.1038/s41598-025-86716-2.

DOI:10.1038/s41598-025-86716-2
PMID:39843907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11754751/
Abstract

Hepatocyte growth factor (HGF) is a substance that stimulates the proliferation of hepatocytes which promote healing. We developed a macrophage membrane-encapsulated nanosphere drug delivery system containing HGF for the study of burn wound healing. Twenty-seven Sprague-Dawley rats were randomly divided into three groups: a saline control (NS) group, an engineered macrophage membrane-encapsulated nanospheres (ETMM@NPS) group, and an engineered macrophage membrane-encapsulated nanospheres treatment with HGF-loaded gene (HGF@ETMM@NPS) group.The wound tissue sections were examined histologically using hematoxylin and eosin (H&E) and Masson trichrome staining. Immunohistochemistry and Western blotting were performed to determine the expression of relevant proteins. The wound-healing, blood flow and complete epithelialization rates were significantly better in the HGF@ETMM@NPS group compared to the NS and ETMM@NPS groups. Expression of B-cell lymphoma 2-associated X-protein was significantly lower, and B-cell lymphoma 2, cluster of differentiation 31, HGF, alpha smooth muscle actin, and PCNA expression was significantly higher in the HGF@ETMM@NPS group compared with the other two groups. PCNA and HGF expression was significantly up-regulated in the HGF@ETMM@NPS group. The HGF@ETMM@NPS complex drug delivery system used in this research promoted wound healing via effective delivery of HGF to burn wounds, thereby accelerating skin cell growth and migration.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/4a66497257c2/41598_2025_86716_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/12667013ed7e/41598_2025_86716_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/14a36a992b69/41598_2025_86716_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/0903620da65e/41598_2025_86716_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/a8ec8886fdd8/41598_2025_86716_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/fe6f3b251e17/41598_2025_86716_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/0f87ff649856/41598_2025_86716_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/72c12910b7f4/41598_2025_86716_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/3a0429a85fbc/41598_2025_86716_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/b410125d93c3/41598_2025_86716_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/e19935fbb5c0/41598_2025_86716_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/4a66497257c2/41598_2025_86716_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/12667013ed7e/41598_2025_86716_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/14a36a992b69/41598_2025_86716_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/0903620da65e/41598_2025_86716_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/a8ec8886fdd8/41598_2025_86716_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/fe6f3b251e17/41598_2025_86716_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/0f87ff649856/41598_2025_86716_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/72c12910b7f4/41598_2025_86716_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/3a0429a85fbc/41598_2025_86716_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/b410125d93c3/41598_2025_86716_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/e19935fbb5c0/41598_2025_86716_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1eb/11754751/4a66497257c2/41598_2025_86716_Fig11_HTML.jpg

相似文献

[1]
Mechanism of engineered macrophage membrane bionic gene-carrying nanospheres for targeted drug delivery to promote wound repair in deep second-degree burns.

Sci Rep. 2025-1-22

[2]
Effects of mesenchymal stem cells transfected with human hepatocyte growth factor gene on healing of burn wounds.

Chin J Traumatol. 2010-12

[3]
Porous Se@SiO nanosphere-coated catheter accelerates prostatic urethra wound healing by modulating macrophage polarization through reactive oxygen species-NF-κB pathway inhibition.

Acta Biomater. 2019-2-10

[4]
[Effects and mechanism of rat epidermal stem cells treated with exogenous vascular endothelial growth factor on healing of deep partial-thickness burn wounds in rats].

Zhonghua Shao Shang Za Zhi. 2020-3-20

[5]
A Composite of Hepatocyte Growth Factor- and 5α-Dihydrotestosterone-Gelatin Microspheres with Adipose-Derived Stem Cells Enhances Wound Healing.

Skin Pharmacol Physiol. 2022

[6]
[Effects and mechanism of hepatocyte growth factor-modified human adipose mesenchymal stem cells on wound healing of full-thickness skin defects in diabetic rats].

Zhonghua Shao Shang Za Zhi. 2021-9-20

[7]
Hepatocyte growth factor and macrophage-stimulating protein are upregulated during excisional wound repair in rats.

Cell Tissue Res. 2001-11

[8]
Gene transfer of human hepatocyte growth factor into rat skin wounds mediated by liposomes coated with the sendai virus (hemagglutinating virus of Japan).

Am J Pathol. 2002-11

[9]
[Effects of exosomes from hepatocyte growth factor-modified human adipose mesenchymal stem cells on full-thickness skin defect in diabetic mice].

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022-11-20

[10]
Release of insulin from PLGA-alginate dressing stimulates regenerative healing of burn wounds in rats.

Clin Sci (Lond). 2015-12

本文引用的文献

[1]
Monosodium Urate Crystal-Induced Pyroptotic Cell Death in Neutrophil and Macrophage Facilitates the Pathological Progress of Gout.

Small. 2024-6

[2]
Cellular and molecular mechanisms in vascular repair after traumatic brain injury: a narrative review.

Burns Trauma. 2023-9-4

[3]
Chinese Herbal Medicine Combined With Antiepileptic Drugs for Intractable Epilepsy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Front Pharmacol. 2022-7-20

[4]
M2 Macrophage Membrane-Mediated Biomimetic-Nanoparticle Carrying COX-siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation.

Small. 2023-8

[5]
Engineering Bifunctional Calcium Alendronate Gene-Delivery Nanoneedle for Synergistic Chemo/Immuno-Therapy Against HER2 Positive Ovarian Cancer.

Adv Sci (Weinh). 2023-5

[6]
Burns: Classification, Pathophysiology, and Treatment: A Review.

Int J Mol Sci. 2023-2-13

[7]
Advances in Antibody-Based Therapeutics for Cerebral Ischemia.

Pharmaceutics. 2022-12-31

[8]
Novel PLCL nanofibrous/keratin hydrogel bilayer wound dressing for skin wound repair.

Colloids Surf B Biointerfaces. 2023-2

[9]
Recent Advances in Lipid Nanoparticles for Delivery of mRNA.

Pharmaceutics. 2022-12-1

[10]
Mesenchymal Stem Cells in Burn Wound Management.

Int J Mol Sci. 2022-12-5

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