Wang Rui-Qi, Deng Zhi-Min, Chen Gan-Tao, Dai Fang-Fang, Xia Liang-Bin
Department of Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Reprod Biol Endocrinol. 2025 Jan 22;23(1):10. doi: 10.1186/s12958-024-01326-3.
Recurrent spontaneous abortion (RSA), characterized by the loss of two or more pregnancies, impacts approximately 1-2% of couples and poses a significant challenge for individuals of childbearing age. The precise mechanisms underlying RSA remain incompletely understood. Concurrently, the global prevalence of obesity is on the rise, with obesity being closely associated with female reproductive disorders and infertility. This study initially examines the pathways through which obesity contributes to RSA, encompassing factors such as embryonic euploid miscarriage, endometrial development, immune function, among others. Furthermore, adipokines and the fat mass and obesity-related (FTO) are identified as potential contributors to RSA. The study also explores the enhancement of pregnancy outcomes through various weight management strategies, with a particular focus on the roles of dietary interventions, physical activity, and weight control during pregnancy. Obesity is closely related to RSA in multiple aspects. Additional clinical prospective and experimental studies are required to explore its precise pathogenesis. Through this review, we aim to provide strategies for improvement and treatment approaches for RSA related to obesity. Through this review, we suggest potential clinical management strategies and research avenues aimed at offering enhancements and therapeutic insights for miscarriages linked to obesity and its associated risk factors.
复发性自然流产（RSA）的特征是两次或更多次妊娠丢失，影响约1%-2%的夫妇，给育龄个体带来重大挑战。RSA的精确潜在机制仍未完全了解。同时，全球肥胖患病率呈上升趋势，肥胖与女性生殖障碍和不孕症密切相关。本研究首先考察肥胖导致RSA的途径，包括胚胎整倍体流产、子宫内膜发育、免疫功能等因素。此外，脂肪因子和肥胖相关基因（FTO）被确定为RSA的潜在促成因素。该研究还探讨了通过各种体重管理策略改善妊娠结局，特别关注孕期饮食干预、体育活动和体重控制的作用。肥胖在多个方面与RSA密切相关。需要更多的临床前瞻性和实验研究来探索其精确发病机制。通过本综述，我们旨在为与肥胖相关的RSA提供改善策略和治疗方法。通过本综述，我们建议了潜在的临床管理策略和研究途径，旨在为与肥胖及其相关风险因素相关的流产提供改善和治疗见解。
