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BMAL1 is a Critical Regulator of Sex-Specific Gene Expression in the Heart.

作者信息

Dierickx Pieterjan

机构信息

Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.

Cardiopulmonary Institute (CPI), 61231 Bad Nauheim, Germany.

出版信息

Function (Oxf). 2025 Feb 12;6(1). doi: 10.1093/function/zqaf004.

DOI:10.1093/function/zqaf004
PMID:39844341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11815577/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c1/11815577/91b9c6931e80/zqaf004fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c1/11815577/91b9c6931e80/zqaf004fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78c1/11815577/91b9c6931e80/zqaf004fig1.jpg

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BMAL1 is a Critical Regulator of Sex-Specific Gene Expression in the Heart.BMAL1是心脏中性别特异性基因表达的关键调节因子。
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New role for cardiomyocyte in the regulation of sex-specific heart transcriptomes.心肌细胞在性别特异性心脏转录组调控中的新作用。
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The Core Circadian Clock Factor, Bmal1, Transduces Sex-specific Differences in Both Rhythmic and Nonrhythmic Gene Expression in the Mouse Heart.核心昼夜节律时钟因子Bmal1传导小鼠心脏节律性和非节律性基因表达中的性别特异性差异。
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Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training.骨骼肌中的BMAL1对于局部和外周组织响应耐力运动训练的转录适应性是必需的。
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本文引用的文献

1
The Core Circadian Clock Factor, Bmal1, Transduces Sex-specific Differences in Both Rhythmic and Nonrhythmic Gene Expression in the Mouse Heart.核心昼夜节律时钟因子Bmal1传导小鼠心脏节律性和非节律性基因表达中的性别特异性差异。
Function (Oxf). 2025 Feb 12;6(1). doi: 10.1093/function/zqae053.
2
Sexual dimorphism of circadian liver transcriptome.昼夜节律性肝脏转录组的性别二态性。
iScience. 2024 Mar 12;27(4):109483. doi: 10.1016/j.isci.2024.109483. eCollection 2024 Apr 19.
3
Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology.
转录抑制因子E4BP4在心脏生理和病理生理中的新作用
JACC Basic Transl Sci. 2023 Jun 14;8(9):1141-1156. doi: 10.1016/j.jacbts.2023.03.016. eCollection 2023 Sep.
4
Voluntary Wheel Running Exercise Does Not Attenuate Circadian and Cardiac Dysfunction Caused by Conditional Deletion of .自愿轮跑运动不能减轻条件性敲除. 引起的昼夜节律和心脏功能障碍。
J Biol Rhythms. 2023 Jun;38(3):290-304. doi: 10.1177/07487304231152398. Epub 2023 Feb 20.
5
Transcriptional control of energy metabolism by nuclear receptors.核受体对能量代谢的转录调控。
Nat Rev Mol Cell Biol. 2022 Nov;23(11):750-770. doi: 10.1038/s41580-022-00486-7. Epub 2022 May 16.
6
Circadian REV-ERBs repress to activate NAMPT-dependent NAD biosynthesis and sustain cardiac function.生物钟 REV-ERBs 抑制 NAD 合成酶(NAMPT)依赖性 NAD 生物合成并维持心脏功能。
Nat Cardiovasc Res. 2022 Jan;1(1):45-58. doi: 10.1038/s44161-021-00001-9. Epub 2021 Dec 23.
7
Sudden cardiac death during nighttime hours.夜间发生心源性猝死。
Heart Rhythm. 2021 May;18(5):778-784. doi: 10.1016/j.hrthm.2020.12.035. Epub 2021 Jan 20.
8
Guidelines for Genome-Scale Analysis of Biological Rhythms.生物节律的全基因组分析指南。
J Biol Rhythms. 2017 Oct;32(5):380-393. doi: 10.1177/0748730417728663. Epub 2017 Nov 3.
9
Female ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy.雌性 ClockΔ19/Δ19 小鼠可免受年龄相关性心肌病的发展影响。
Cardiovasc Res. 2018 Feb 1;114(2):259-271. doi: 10.1093/cvr/cvx185.
10
Circadian networks in human embryonic stem cell-derived cardiomyocytes.人胚胎干细胞衍生心肌细胞中的昼夜节律网络。
EMBO Rep. 2017 Jul;18(7):1199-1212. doi: 10.15252/embr.201743897. Epub 2017 May 23.