Zhou Yijun, Ampon Maria R, Abramson Michael J, James Alan L, Maguire Graeme P, Wood-Baker Richard, Johns David P, Marks Guy B, Reddel Helen K, Toelle Brett G
The Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.
Australian Centre for Airways Disease Monitoring, The Woolcock Institute of Medical Research, The University of Sydney, Glebe, Australia.
Chron Respir Dis. 2025 Jan-Dec;22:14799731241312687. doi: 10.1177/14799731241312687.
Individuals with Preserved Ratio Impaired Spirometry (PRISm), defined as FEV/FVC ≥0.7 and FEV1 <80% predicted, are at higher risk of developing COPD. However, data for Australian adults are limited. We aimed to describe prevalence of PRISm and its relationship with clinical characteristics in Australia. Data from the Burden of Lung Disease (BOLD) Australia study of randomly selected adults aged ≥40 years from six sites was classified into airflow limitation, PRISm, or normal spirometry groups. Demographic, clinical characteristics, and lung function were compared between groups. Of the study sample ( = 3518), 387 (11%) had PRISm, 549 (15.6%) had airflow limitation, and 2582 (73.4%) had normal spirometry. PRISm was more common in Indigenous Australian adults. Adults with PRISm had more frequent respiratory symptoms, more comorbidities, greater health burden and poorer quality of life than those with normal spirometry. Pre- and post-bronchodilator FEV and FVC were lower in adults with PRISm than those with airflow limitation. Adults with PRISm were less likely to use respiratory medicine than those with airflow limitation (OR = 0.56, 95% CI 0.38-0.81). PRISm was present in 11% of adults in this study and they had similar respiratory symptoms and health burden as adults with airflow limitation.
肺量计测定比值保留但肺功能受损（PRISm）的个体，定义为FEV/FVC≥0.7且FEV1<预测值的80%，其患慢性阻塞性肺疾病（COPD）的风险更高。然而，澳大利亚成年人的数据有限。我们旨在描述澳大利亚PRISm的患病率及其与临床特征的关系。来自澳大利亚肺部疾病负担（BOLD）研究的数据，该研究对从六个地点随机选取的年龄≥40岁的成年人进行了分类，分为气流受限、PRISm或肺量计测定正常组。比较了各组之间的人口统计学、临床特征和肺功能。在研究样本（n = 3518）中，387人（11%）患有PRISm，549人（15.6%）存在气流受限，2582人（73.4%）肺量计测定正常。PRISm在澳大利亚原住民成年人中更为常见。与肺量计测定正常的成年人相比，患有PRISm的成年人有更频繁的呼吸道症状、更多的合并症、更大的健康负担和更差的生活质量。与气流受限的成年人相比，患有PRISm的成年人支气管扩张剂使用前和使用后的FEV和FVC更低。与气流受限的成年人相比，患有PRISm的成年人使用呼吸药物的可能性更小（比值比=0.56，95%置信区间0.38 - 0.81）。本研究中11%的成年人患有PRISm，他们具有与气流受限成年人相似的呼吸道症状和健康负担。
