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Myeloma cell growth suppression by osteoblast-derived extracellular vesicles: the creation of a non-permissive niche for myeloma cells by bone-forming osteoblasts.

作者信息

Kim SooHa, Teramachi Jumpei, Hiasa Masahiro, Amachi Ryota, Bat-Erdene Ariunzaya, Oda Asuka, Tenshin Hirofumi, Tanaka Mariko, Nakagawa Motosumi, Seki Aiko, Sawa Yoshihiko, Matsuoka Ken-Ichi, Tanaka Eiji, Harada Takeshi, Tominaga Tatsuya, Abe Masahiro

机构信息

Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan; Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima.

Department of Oral Function and Anatomy, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University.

出版信息

Haematologica. 2025 Jun 1;110(6):1395-1401. doi: 10.3324/haematol.2024.286554. Epub 2025 Jan 23.

DOI:10.3324/haematol.2024.286554
PMID:39844765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12130788/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f05a/12130788/b89b9951b29f/1101395.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f05a/12130788/dcb1ccbb49c9/1101395.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f05a/12130788/871ffe2e46b0/1101395.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f05a/12130788/b89b9951b29f/1101395.fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f05a/12130788/dcb1ccbb49c9/1101395.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f05a/12130788/871ffe2e46b0/1101395.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f05a/12130788/b89b9951b29f/1101395.fig3.jpg

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本文引用的文献

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Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation.成骨细胞中 miR-125b 的过表达通过抑制破骨细胞形成改善与年龄相关的骨量和骨质量变化。
Int J Mol Sci. 2021 Jun 23;22(13):6745. doi: 10.3390/ijms22136745.
2
The Emerging Roles of miR-125b in Cancers.微小RNA-125b在癌症中的新兴作用
Cancer Manag Res. 2020 Feb 12;12:1079-1088. doi: 10.2147/CMAR.S232388. eCollection 2020.
3
The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice.
基质小泡携带的 miR-125b 在骨基质中积累，抑制了小鼠的骨吸收。
Commun Biol. 2020 Jan 16;3(1):30. doi: 10.1038/s42003-020-0754-2.
4
Increased Osteoblastic Activity Suppressed Proliferation of Multiple Myeloma Plasma Cells.成骨细胞活性增加抑制多发性骨髓瘤浆细胞增殖。
Spine (Phila Pa 1976). 2019 Apr 1;44(7):E384-E392. doi: 10.1097/BRS.0000000000002873.
5
Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo.通过合成的微小RNA-125b-5p模拟物对IRF4进行选择性靶向在体外和体内诱导抗多发性骨髓瘤活性。
Leukemia. 2015 Nov;29(11):2173-83. doi: 10.1038/leu.2015.124. Epub 2015 May 19.
6
MicroRNA-125b potentiates macrophage activation.microRNA-125b 增强巨噬细胞的激活。
J Immunol. 2011 Nov 15;187(10):5062-8. doi: 10.4049/jimmunol.1102001. Epub 2011 Oct 14.
7
MicroRNA 125b inhibition of B cell differentiation in germinal centers.MicroRNA 125b 抑制生发中心 B 细胞分化。
Int Immunol. 2010 Jul;22(7):583-92. doi: 10.1093/intimm/dxq042. Epub 2010 May 23.
8
Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth.TGF-β 抑制可恢复终末成骨细胞分化，从而抑制骨髓瘤生长。
PLoS One. 2010 Mar 25;5(3):e9870. doi: 10.1371/journal.pone.0009870.
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IRF4 addiction in multiple myeloma.多发性骨髓瘤中的IRF4成瘾
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