Reid Katelyn R, Tabibi Alireza, Adami Parisa, Karimi Benson
Department of Physical and Environmental Sciences, Texas A&M University Corpus Christi, Corpus Christi, TX, 78412, USA.
Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
Heliyon. 2024 Dec 19;11(1):e41398. doi: 10.1016/j.heliyon.2024.e41398. eCollection 2025 Jan 15.
Heparin is a highly valuable active pharmaceutical ingredient, typically derived from porcine intestinal mucosa. Traditionally, various commercial resins have been used as adsorbents for heparin extraction; however, there has been growing interest in exploring more cost-effective adsorbents in recent years to improve heparin recovery. Zeolites, a typical aluminosilicate known for their high surface area, porosity, and thermal stability, were selected for evaluation in this study. We investigated the performance of two different zeolites, CBV901 and CBV10A, in recovering heparin. Our findings indicate that the CBV901 zeolite exhibits excellent efficiency (44 %) along with capacity (23.3 mg.g-1) for adsorption when used with porcine intestinal mucosa. A mechanistic analysis using kinetic and thermodynamic models revealed that the surface conditions were favorable for heparin adsorption. Additionally, we examined the effects of various conditions including adsorption time, as well as sorbent reusability for recovery process refinement.
肝素是一种非常有价值的活性药物成分，通常从猪肠黏膜中提取。传统上，各种商业树脂已被用作肝素提取的吸附剂；然而，近年来人们越来越有兴趣探索更具成本效益的吸附剂，以提高肝素的回收率。沸石是一种典型的铝硅酸盐，以其高表面积、孔隙率和热稳定性而闻名，本研究选择对其进行评估。我们研究了两种不同的沸石CBV901和CBV10A在回收肝素方面的性能。我们的研究结果表明，当与猪肠黏膜一起使用时，CBV901沸石在吸附方面表现出优异的效率（44%）和容量（23.3 mg·g-1）。使用动力学和热力学模型进行的机理分析表明，表面条件有利于肝素吸附。此外，我们还研究了各种条件的影响，包括吸附时间，以及吸附剂的可重复使用性，以优化回收过程。
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