Serati-Nouri Hamed, Jafari Amir, Roshangar Leila, Dadashpour Mehdi, Pilehvar-Soltanahmadi Younes, Zarghami Nosratollah
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111225. doi: 10.1016/j.msec.2020.111225. Epub 2020 Jun 20.
Zeolites are crystalline, hydrated aluminosilicates of alkali earth cations, consisting of 3D frameworks of [SiO] and [AlO] tetrahedral, linked through the shared oxygen atoms, which have been widely applied in multifarious technological approaches such as adsorbents, catalysts, ion exchangers, molecular sieves for separation, and sorting the molecules according to their crystalline size dimensions. On the other hand, the unique and outstanding physical and chemical properties of zeolite materials such as porous character, ion exchangeability, water absorption capacity, immunomodulatory and antioxidative effects, biocompatibility and long-term chemical and biological stability, make them increasingly useful in various filed of biomedicine including drug delivery systems, wound healing, scaffolds used in tissue engineering, anti-bacterial and anti-microbial, implant coating, contrast agents, harmful ions removal from the body, gas absorber, hemodialysis, and teeth root filling. Therefore, this review focuses on the more recent advances of the use of zeolites in various biomedical applications feedbacks especially drug delivery, regenerative medicine, and tissue engineering with special emphasis on their biomaterial perspectives.
沸石是碱土金属阳离子的结晶水合铝硅酸盐，由[SiO]和[AlO]四面体的三维骨架组成，通过共享氧原子相连，已广泛应用于多种技术领域，如吸附剂、催化剂、离子交换剂、用于分离的分子筛，以及根据分子的晶体尺寸进行分类。另一方面，沸石材料独特而优异的物理和化学性质，如多孔性、离子交换性、吸水能力、免疫调节和抗氧化作用、生物相容性以及长期的化学和生物稳定性，使其在生物医学的各个领域越来越有用，包括药物递送系统、伤口愈合、组织工程中使用的支架、抗菌和抗微生物、植入物涂层、造影剂、从体内去除有害离子、气体吸收器、血液透析和牙根填充。因此，本综述重点关注沸石在各种生物医学应用反馈中的最新进展，特别是药物递送、再生医学和组织工程，并特别强调其生物材料视角。
