Kostandov E A, Arzumanov Iu L, Tal'tse M F
Zh Vyssh Nerv Deiat Im I P Pavlova. 1985 Jan-Feb;35(1):52-9.
Intramuscular injections of seduxen (10 mg), a benzodiasepin drug, with expressed tranquilizing and alarm suppressing effects, were used with the aim of experimental testing of a hypothesis on the neural mechanism of conditioned changes of the P300 wave. Under the action of seduxen no temporary connections could be formed between a perceived nonverbal visual stimulus and a unrecognized emotional word. The seduxen did not suppress the conditioned cortical reaction acquired due to combination of nonverbal stimulus with unrecognized emotional word. The suggestion is made that the necessary condition of temporary connection elaboration by means of a unrecognized verbal stimulus is the implication of the limbic structures where negative emotional reactions are integrated.
肌肉注射速可眠（10毫克），一种具有明显镇静和抑制惊恐作用的苯二氮卓类药物，用于对P300波条件性变化的神经机制假说进行实验测试。在速可眠的作用下，感知到的非言语视觉刺激与未识别的情感词汇之间无法形成暂时联系。速可眠并未抑制由于非言语刺激与未识别的情感词汇相结合而获得的条件性皮层反应。有人提出，借助未识别的言语刺激形成暂时联系的必要条件是边缘结构的参与，在边缘结构中负面情绪反应得以整合。
