Song Yagang, Tian Shuo, Li Zhanzhan, Miao Jinxin, Wu Mingming, Xu Tingli, Wu Xiangxiang, Qiao Jingyi, Zhang Xialei, Zhao Hui, Kang Le, Cao Lihua, Zhu Pingsheng, Miao Mingsan
Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People's Republic of China.
Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People's Republic of China.
J Hepatocell Carcinoma. 2025 Jan 18;12:59-76. doi: 10.2147/JHC.S496964. eCollection 2025.
The intratumoral microbiota, an integral part of liver tumors, has garnered significant attention from researchers due to its role in tumor development regulation and impact on cancer treatment. Intratumoral microorganism not only influences tumorigenesis and progression, but also serves as potential biomarkers and targets for tumor therapy. Targeted manipulation of these microorganisms holds great promise for personalized liver cancer treatment. However, there is a lack of systematic summaries and reports on the study of intratumoral microorganism in hepatocellular carcinoma. This comprehensive review aims to address this gap by summarizing research progress related to in the field of hepatocellular carcinoma intratumoral bacteria, including their sources, types, distribution characteristics within tumors, impact on tumor development, underlying mechanisms, and application prospects. Through the analysis, it is proposed that intratumor organisms can be used as markers for liver cancer diagnosis and treatment, drug carrier materials for targeting liver cancer tissues, and the research prospects of developing new combination therapies based on the in-depth understanding of the interactions between intratumor microorganisms and the tumor microenvironment, immune cells, liver cancer cells, etc. as well as exploring the prospects of developing new combination therapies based on these interactions. It is hoped that from the perspective of intratumoral microbiota, potential theoretical support can be provided for future research on targeted cancer therapy for liver cancer intratumoral microbiota, and new insights and ideas can be provided for targeting points and research methods in tumor research.
肿瘤内微生物群是肝肿瘤的一个组成部分，因其在肿瘤发展调控中的作用以及对癌症治疗的影响而受到研究人员的广泛关注。肿瘤内微生物不仅影响肿瘤的发生和进展，还可作为肿瘤治疗的潜在生物标志物和靶点。对这些微生物进行靶向调控有望实现肝癌的个性化治疗。然而，目前缺乏关于肝细胞癌肿瘤内微生物研究的系统总结和报道。本综述旨在通过总结肝细胞癌肿瘤内细菌领域的研究进展来填补这一空白，内容包括其来源、类型、在肿瘤内的分布特征、对肿瘤发展的影响、潜在机制以及应用前景。通过分析，提出肿瘤内微生物可作为肝癌诊断和治疗的标志物、靶向肝癌组织的药物载体材料，以及基于深入了解肿瘤内微生物与肿瘤微环境、免疫细胞、肝癌细胞等之间的相互作用开发新联合疗法的研究前景。希望从肿瘤内微生物群的角度，为未来肝癌肿瘤内微生物群靶向癌症治疗的研究提供潜在的理论支持，并为肿瘤研究中的靶点和研究方法提供新的见解和思路。
