Lee Nae-Ho, Park Jung Kyun, Roh Si-Gyun, Shin Jin Yong, Chung Yoon Kyu, Jang Kyu Yun
Department of Plastic and Reconstructive Surgery, Medical School of Jeonbuk National University, Jeonju, Republic of Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea.
Arch Plast Surg. 2024 Dec 24;52(1):21-24. doi: 10.1055/s-0044-1792022. eCollection 2025 Jan.
Malignant pilomatricoma, an extremely rare tumor arising from hair follicles, most commonly occurs on the head, neck, and back. This tumor exhibits several noteworthy characteristics. First, it frequently recurs if it is incompletely excised and can occasionally metastasize to the lungs, bones, and lymph nodes. Additionally, it possesses unique histological features that aid in differentiating it from its benign counterpart, including atypical cells, multiple mitoses with ghost cells, nuclear polymorphisms, and necrosis accompanied by serial desmoplasia. While no definitive criteria have been established for the surgical management of this malignant tumor, it is recommended to perform wide local excision with a safety margin of at least ≥5 mm. To the best of our knowledge, very few cases of malignant pilomatricoma with lung metastasis have been reported in Korea. Here we report the case of a patient diagnosed of malignant pilomatricoma with lung metastasis who underwent wide local excision for a lesion on the flank.
恶性毛母质瘤是一种极其罕见的起源于毛囊的肿瘤，最常发生于头、颈和背部。该肿瘤具有几个值得注意的特征。首先，如果切除不完全，它经常会复发，并且偶尔会转移至肺、骨和淋巴结。此外，它具有独特的组织学特征，有助于将其与良性对应物区分开来，包括非典型细胞、伴有影细胞的多个有丝分裂、核多态性以及伴有连续促纤维组织增生的坏死。虽然对于这种恶性肿瘤的手术治疗尚未确立明确的标准，但建议进行至少≥5毫米安全切缘的广泛局部切除。据我们所知，韩国报道的伴有肺转移的恶性毛母质瘤病例非常少。在此，我们报告一例被诊断为伴有肺转移的恶性毛母质瘤患者，该患者因侧腹病变接受了广泛局部切除。
