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一种使用经胫骨转运(TTT)来处理坏死性软组织感染手术治疗后血栓栓塞事件的新方法:病例报告。

A novel approach of using transtibial transport (TTT) to manage thromboembolic events following surgical management of necrotizing soft tissue infection: a case report.

作者信息

Boey Johnson, Lee Jordon, Zhou ZheGang

机构信息

Dr Foot Podiatry Clinic, Singapore, Singapore.

Department of Hand and Microsurgery, Peking University Shenzhen Hospital, Shenzhen, China.

出版信息

Front Med (Lausanne). 2025 Jan 7;11:1481388. doi: 10.3389/fmed.2024.1481388. eCollection 2024.

Abstract

Necrotising soft tissue infections (NSTIs) are one of the most challenging and severe forms of infections. The prognosis requires accurate and aggressive diagnosis and management. In this case, we present an unexplained case of concurrence of TE events following BKA for the surgical management of NSTI. As with the standard management, the first step involves aggressive surgical debridement of non-viable tissue which eventually lead to below-knee amputation for effective source control. Lower limb endovascular angioplasty was attempted but unsuccessful. The PAD was managed with antithrombotic therapy. In spite of this, the patient developed thromboembolic events 1 week following BKA. In response, the antiplatelet therapy with low-molecular weight heparin was enhanced. Transtibial transport was performed after patient found to have stenosis in distal tibial arteries, which the patient refused any further vascular intervention. Nonetheless, with meticulous planning and concerted team efforts, we successfully reversed TE events and salvaged the contralateral limb without the need for amputation. With intensive rehabilitation, the patient was able to return to their pre-morbid functional quality of life.

摘要

坏死性软组织感染(NSTIs)是最具挑战性和严重性的感染形式之一。其预后需要准确且积极的诊断与治疗。在此病例中,我们呈现了一例在因NSTI进行手术治疗行膝下截肢(BKA)后出现不明原因的血栓栓塞(TE)事件并发的病例。与标准治疗一样,第一步是积极手术清创坏死组织,最终导致膝下截肢以有效控制感染源。尝试了下肢血管腔内血管成形术但未成功。外周动脉疾病(PAD)采用抗血栓治疗。尽管如此,患者在BKA后1周出现了血栓栓塞事件。对此,增强了低分子量肝素的抗血小板治疗。在发现患者胫前动脉远端狭窄后进行了经胫骨转移,患者拒绝任何进一步的血管干预。尽管如此,通过精心规划和团队协同努力,我们成功逆转了TE事件并挽救了对侧肢体,无需截肢。经过强化康复,患者能够恢复到病前的功能生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d2b/11753221/164d13504a60/fmed-11-1481388-g001.jpg

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