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二甲双胍作为免疫调节剂的文献计量分析（2013 - 2024年）

Bibliometric analysis of metformin as an immunomodulator (2013-2024).

作者信息

Zhou Tongyi, Yu Yunfeng, Li Liu, Liu Xiu, Xiang Qin, Yu Rong

机构信息

School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.

Hunan Key Laboratory of Traditional Chinese Medicine Prescription and Syndromes Translational Medicine, Hunan University of Chinese Medicine, Changsha, China.

出版信息

Front Immunol. 2025 Jan 8;15:1526481. doi: 10.3389/fimmu.2024.1526481. eCollection 2024.

DOI:10.3389/fimmu.2024.1526481
PMID:39845945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11750822/
Abstract

BACKGROUND

Metformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited.

METHODS

This study extracted 640 relevant articles from the Web of Science (WOS) Core Collection and conducted visual analyses using Microsoft Excel, VOSviewer, and CiteSpace.

RESULTS

The findings showed that research on the immunomodulatory function of metformin has grown steadily since 2017, with China and the United States being the leading contributors. These studies have mostly been published in journals such as . Keyword co-occurrence analysis highlighted metformin's role as an immunomodulator, particularly in the context of the tumor immune microenvironment, immunosuppressive checkpoints, and metformin derivatives. Recent research has highlighted metformin's application in aging, autoimmune diseases, COVID-19, and tuberculosis. Additionally, its role in regulating inflammation and gut microbiota is also being investigated.

CONCLUSION

Overall, the immunomodulatory effects of metformin were investigated in anti-tumor, antiviral, anti-aging, and autoimmune disease research. This highlights the scope of metformin use in these fields, while also significantly enhancing its clinical value as a repurposed drug.

摘要

背景

二甲双胍作为糖尿病的一线治疗药物，具有相当大的免疫调节潜力；然而，关于这一主题的详细文献计量分析有限。

方法

本研究从科学网（WOS）核心合集中提取了640篇相关文章，并使用Microsoft Excel、VOSviewer和CiteSpace进行了可视化分析。

结果

研究结果表明，自2017年以来，关于二甲双胍免疫调节功能的研究稳步增长，中国和美国是主要贡献者。这些研究大多发表在诸如……等期刊上。关键词共现分析突出了二甲双胍作为免疫调节剂的作用，特别是在肿瘤免疫微环境、免疫抑制检查点和二甲双胍衍生物的背景下。最近的研究突出了二甲双胍在衰老、自身免疫性疾病、COVID-19和结核病中的应用。此外，其在调节炎症和肠道微生物群方面的作用也在研究中。

结论

总体而言，在抗肿瘤、抗病毒、抗衰老和自身免疫性疾病研究中对二甲双胍的免疫调节作用进行了研究。这突出了二甲双胍在这些领域的应用范围，同时也显著提高了其作为一种重新利用药物的临床价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/a37e73417ba8/fimmu-15-1526481-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/77c0feb2a90b/fimmu-15-1526481-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/33db9b90a8c4/fimmu-15-1526481-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/ee895a22949e/fimmu-15-1526481-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/90a91e9d97c8/fimmu-15-1526481-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/53d4d77fa338/fimmu-15-1526481-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/5ed59b1e2908/fimmu-15-1526481-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/b62cf2e34d7e/fimmu-15-1526481-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/5250af5a0afc/fimmu-15-1526481-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/addf3e9aa08f/fimmu-15-1526481-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/a37e73417ba8/fimmu-15-1526481-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/77c0feb2a90b/fimmu-15-1526481-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/33db9b90a8c4/fimmu-15-1526481-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/ee895a22949e/fimmu-15-1526481-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/90a91e9d97c8/fimmu-15-1526481-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/53d4d77fa338/fimmu-15-1526481-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/5ed59b1e2908/fimmu-15-1526481-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/b62cf2e34d7e/fimmu-15-1526481-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/5250af5a0afc/fimmu-15-1526481-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/addf3e9aa08f/fimmu-15-1526481-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d502/11750822/a37e73417ba8/fimmu-15-1526481-g010.jpg

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