肠道微生物群与眼部疾病：文献计量学研究与可视化分析。

INTRODUCTION: Recently the role of gut microbial dysbiosis in many ocular disorders, including but not limited to uveitis, age-related macular degeneration (AMD), diabetic retinopathy (DR), dry eye, keratitis and orbitopathy is a hot research topic in the field. Targeting gut microbiota to treat these diseases has become an unstoppable trend. Bibliometric study and visualization analysis have become essential methods for literature analysis in the medical research field. We aim to depict this area's research hotspots and future directions by bibliometric software and methods. METHODS: We search all the related publications from the Web of Science Core Collection. Then, CiteSpace was applied to analyze and visualize the country distributions, dual-map overlay of journals, keyword bursts, and co-cited references. VOSviewer was employed to identify authors, co-cited authors, journals and co-cited journals and display the keyword co-occurrence networks. RESULTS: A total of 284 relevant publications were identified from 2009 to 2023. The number of studies has been small in the first five years and has grown steadily since 2016. These studies were completed by 1,376 authors from 41 countries worldwide, with the United States in the lead. Lin P has published the most papers while Horai R is the most co-cited author. The top journal and co-cited journal are both Investigative Ophthalmology & Visual Science. In the keyword co-occurrence network, except gut microbiota, inflammation becomes the keyword with the highest frequency. Co-citation analyses reveal that gut dysbiosis is involved in common immune- and inflammation-mediated eye diseases, including uveitis, diabetic retinopathy, age-related macular degeneration, dry eye, and Graves' orbitopathy, and the study of microbiomes is no longer limited to the bacterial populations. Therapeutic strategies that target the gut microbiota, such as probiotics, healthy diet patterns, and fecal microbial transplantation, are effective and critical to future research. CONCLUSIONS: In conclusion, the bibliometric analysis displays the research hotspots and developmental directions of the involvement of gut microbiota in the pathogenesis and treatment of some ocular diseases. It provides an overview of this field's dynamic evolution and structural relationships.

简介：最近，肠道微生物失调在许多眼部疾病中的作用，包括但不限于葡萄膜炎、年龄相关性黄斑变性 (AMD)、糖尿病视网膜病变 (DR)、干眼症、角膜炎和眼眶病，成为该领域的热门研究课题。针对肠道微生物群治疗这些疾病已成为一种不可阻挡的趋势。文献计量学研究和可视化分析已成为医学研究领域文献分析的必要方法。我们旨在通过文献计量学软件和方法描绘该领域的研究热点和未来方向。

方法：我们从 Web of Science 核心合集搜索所有相关出版物。然后，使用 CiteSpace 分析和可视化国家分布、期刊双图叠加、关键词爆发和共被引参考文献。使用 VOSviewer 识别作者、共被引作者、期刊和共被引期刊，并显示关键词共现网络。

结果：从 2009 年到 2023 年，共确定了 284 篇相关出版物。前五年的研究数量较少，自 2016 年以来稳步增长。这些研究由来自全球 41 个国家的 1376 位作者完成，美国位居首位。Lin P 发表的论文最多，而 Horai R 是最被引用的作者。排名最高的期刊和共被引期刊都是《眼科与视觉研究》。在关键词共现网络中，除了肠道微生物群，炎症成为出现频率最高的关键词。共被引分析表明，肠道失调与常见的免疫和炎症介导的眼部疾病有关，包括葡萄膜炎、糖尿病视网膜病变、年龄相关性黄斑变性、干眼症和格雷夫斯眼病，对微生物组的研究不再局限于细菌群体。针对肠道微生物群的治疗策略，如益生菌、健康饮食模式和粪便微生物移植，是有效的，对未来的研究至关重要。

结论：综上所述，文献计量学分析展示了肠道微生物群在一些眼部疾病发病机制和治疗中的作用的研究热点和发展方向。它提供了该领域动态演变和结构关系的概述。