Al'perovich P M, Alimbek S Kh
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(2):167-72.
The data obtained by the authors refute the generally accepted opinion to the effect that Schilder's encephalitis is a very rare disease predominantly affecting children. Clinical and neurohistological examinations of 16 patients have made it possible to establish that demyelinization foci may affect all portions of the brain, being found, however, more commonly in the frontal and occipital lobes, basal ganglia and brain stem. The spinal cord is also frequently involved. The clinical picture of the disease is polymorphic and reflects multiple lesions of the associative and projectional conductive pathways. The most consistent findings include mental disturbances and symptoms of pyramidal tract affection. The development and course of the disease are variable. In some cases long-term relapses may develop.
作者获得的数据反驳了普遍接受的观点，即席尔德脑炎是一种非常罕见的疾病，主要影响儿童。对16例患者进行的临床和神经组织学检查表明，脱髓鞘病灶可能累及大脑的所有部位，然而，更常见于额叶和枕叶、基底神经节和脑干。脊髓也经常受累。该病的临床表现具有多形性，反映了联合和投射传导通路的多处病变。最一致的发现包括精神障碍和锥体束受累的症状。疾病的发展和病程各不相同。在某些情况下，可能会出现长期复发。
