Lana-Peixoto M A, dos Santos E C
Department of Neurology, Federal University of Minas Gerais Medical School, Belo Horizonte, Brazil.
J Clin Neuroophthalmol. 1989 Dec;9(4):236-40; discussion 241.
We report here a case of Schilder's myelinoclastic diffuse sclerosis in a 14-year-old girl with sudden bilateral visual loss. Computed tomographic scan showed two large symmetrical lesions in the occipital lobes and a smaller hypodense area in the frontal lobe. Cerebrospinal fluid examination revealed increased immunoglobulin G fraction with the presence of oligoclonal bands. Ultrastructural study of a biopsy specimen disclosed a demyelinating disorder with no cytoplasmic inclusions. Steroid treatment was followed by a dramatic response, with almost complete visual recovery and shrinkage of the lesions.
我们在此报告一例14岁突发双侧视力丧失的女孩患席尔德髓鞘破坏弥漫性硬化症的病例。计算机断层扫描显示枕叶有两个大的对称病灶，额叶有一个较小的低密度区。脑脊液检查显示免疫球蛋白G分数升高且存在寡克隆带。活检标本的超微结构研究显示为脱髓鞘疾病，无细胞质包涵体。类固醇治疗后有显著反应，视力几乎完全恢复，病灶缩小。
