Philibert Robert, Beach Steven R H, Andersen Allan M
Department of Psychiatry, University of Iowa, Iowa City, IA 52246, USA.
Behavioral Diagnostics LLC, Coralville, IA 52241, USA.
Epigenomes. 2024 Dec 24;9(1):1. doi: 10.3390/epigenomes9010001.
Heavy alcohol consumption (HAC) has a profound adverse effect on human health. Unfortunately, there is a relative lack of tools that are easily implementable in clinical settings and that can be used to supplement self-reporting in the diagnosis and management of HAC. In part, this paucity is due to limitations of currently available biological measures and a mismatch between available biological measures and the needs of clinicians managing HAC.
We first review the pros and cons of existing biological measures. Next, we review the underlying theory and the performance characteristics of two recently developed methylation-sensitive digital PCR (MSdPCR) assays, referred to as the Alcohol T Score (ATS) and ZSCAN25, for the assessment of chronic and recent HAC, respectively. Finally, we outline a paradigm for improving the clinical diagnosis and management of alcohol use disorders by utilizing these new markers of alcohol consumption.
We conclude that further studies to understand the test performance characteristics of each of these epigenetic tools in larger, diverse populations are in order.
大量饮酒对人类健康有深远的不良影响。不幸的是，相对缺乏易于在临床环境中实施且可用于补充自我报告以诊断和管理大量饮酒的工具。部分原因在于当前可用生物检测方法的局限性，以及可用生物检测方法与管理大量饮酒的临床医生需求之间的不匹配。
我们首先回顾现有生物检测方法的优缺点。接下来，我们回顾两种最近开发的甲基化敏感数字PCR（MSdPCR）检测方法的基础理论和性能特征，分别称为酒精T评分（ATS）和ZSCAN25，用于评估慢性和近期大量饮酒情况。最后，我们概述一种利用这些新的饮酒标志物改善酒精使用障碍临床诊断和管理的范例。
我们得出结论，有必要开展进一步研究，以了解这些表观遗传工具在更大、更多样化人群中的检测性能特征。
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