Vulpe Diana Elena, Nedelea Dana-Georgiana, Dragosloveanu Serban, Sandulescu Oana, Scheau Cristian
Doctoral School, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Orthopaedics, "Foisor" Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania.
Infect Dis Rep. 2025 Jan 10;17(1):6. doi: 10.3390/idr17010006.
Spondylodiscitis can be caused by various microorganisms and has shown a continuous rise in incidence and mortality. The purpose of our study was to analyze the demographic and laboratory data, as well as comorbidities of patients that were surgically treated for spondylodiscitis in our hospital. The causative pathogens involved in the etiology of spinal infections were also assessed. The study included 92 patients who underwent clinical, radiological, and microbiological analyses including bacterial isolation. According to their culture results, patients were divided into three groups: negative results ( 29), positive results with (M. tb.) ( 26), and positive results with other pathological agents ( 37). Patients with M. tb. had a significantly lower body mass index ( = 0.022) and were significantly younger ( = 0.024) than the others. The analysis of the complete blood work showed significant differences between the groups regarding fibrinogen levels ( = 0.023), C-reactive protein ( = 0.009), and erythrocyte sedimentation rates ( = 0.042). Results also showed significant differences ( = 0.023) for patients with diabetes mellitus who were more prone to a tuberculosis etiology for their spondylodiscitis compared with patients without the disease. These findings have important implications for adopting individualized treatment strategies underlining the need for identification of patients at high risk for specific causative pathogens.
脊椎椎间盘炎可由多种微生物引起，其发病率和死亡率持续上升。我们研究的目的是分析在我院接受手术治疗的脊椎椎间盘炎患者的人口统计学和实验室数据以及合并症。还评估了脊柱感染病因中涉及的致病病原体。该研究纳入了92例接受临床、放射学和微生物学分析（包括细菌分离）的患者。根据培养结果，患者被分为三组：阴性结果组（29例）、结核分枝杆菌阳性结果组（26例）和其他病原体阳性结果组（37例）。结核分枝杆菌感染患者的体重指数显著较低（P = 0.022），且比其他患者明显年轻（P = 0.024）。全血细胞分析显示，各组之间在纤维蛋白原水平（P = 0.023）、C反应蛋白（P = 0.009）和红细胞沉降率（P = 0.042）方面存在显著差异。结果还显示，与无糖尿病患者相比，糖尿病患者发生脊椎椎间盘炎时更易由结核病因引起，差异有统计学意义（P = 0.023）。这些发现对于采用个体化治疗策略具有重要意义，强调了识别特定致病病原体高危患者的必要性。
