了解电压门控钠离子通道突变在心血管疾病中的作用。
Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders.
作者信息
Jorgensen Christian
机构信息
School of Medicine, Pharmacy and Biomedical Sciences, Faculty of Science & Health, University of Portsmouth , Portsmouth, UK.
出版信息
J Gen Physiol. 2025 Mar 3;157(2). doi: 10.1085/jgp.202413744. Epub 2025 Jan 23.
Abstract
Elhanafy et al. used Molecular Dynamics simulations and electrophysiology to show how identical mutations in the volgage sending domain of sodium channels can yield differential functional effects.
摘要
埃尔哈纳菲等人利用分子动力学模拟和电生理学方法，展示了钠通道电压传感结构域中的相同突变如何产生不同的功能效应。
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