Stockmann Olga, Ye Lan, Greten Stephan, Chemodanow David, Wegner Florian, Klietz Martin
Department of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.
J Neural Transm (Vienna). 2025 May;132(5):627-635. doi: 10.1007/s00702-025-02882-7. Epub 2025 Jan 23.
Parkinson's disease (PD) is a chronic neurodegenerative disease of the elderly. Patients suffer from progressive motor and non-motor symptoms. Further, PD patients often present geriatric features like multimorbidity and polypharmacotherapy. A frequent comorbidity of PD patients is diabetes mellitus type two (T2DM). In the last decade growing evidence emerged on the impact of T2DM on PD. Of the present review was to analyze the impact of T2DM on PD incidence and progression in patient cohorts. A systematic review of the literature was performed via PubMed and Google Scholar. Studies on longitudinal PD patient cohorts with at least 10 patients per group were included. The diabetic state of the patient had to be determined. In total, 15 studies were analyzed for this review. According to most of the included studies T2DM increases the risk of developing PD significantly. Disease progression is augmented by T2DM both for motor and cognitive impairments. Some studies also point out a correlation of motor worsening and diabetic status measured by the serum HbA1c level. In relation to biomarkers, PD patients with diabetes have higher neurofilament light chain and Tau level but lower Amyloid beta level. T2DM seems to be a risk factor for the development and progression of PD. PD patients should be screened for T2DM and treatment should be initiated promptly. There is still a lack of knowledge about the molecular mechanisms leading to interactions of these diseases.
帕金森病（PD）是一种老年人的慢性神经退行性疾病。患者会出现进行性运动和非运动症状。此外，帕金森病患者常呈现出多种老年病特征，如多病共存和多药治疗。帕金森病患者常见的合并症是2型糖尿病（T2DM）。在过去十年中，越来越多的证据表明T2DM对帕金森病有影响。本综述旨在分析T2DM对患者队列中帕金森病发病率和进展的影响。通过PubMed和谷歌学术对文献进行了系统综述。纳入了对每组至少有10名患者的帕金森病纵向患者队列的研究。必须确定患者的糖尿病状态。本综述共分析了15项研究。根据大多数纳入研究，T2DM显著增加了患帕金森病的风险。T2DM会加剧运动和认知障碍方面的疾病进展。一些研究还指出，运动恶化与通过血清糖化血红蛋白水平衡量的糖尿病状态之间存在关联。在生物标志物方面，患有糖尿病的帕金森病患者神经丝轻链和 Tau 水平较高，但淀粉样β水平较低。T2DM似乎是帕金森病发生和发展的一个危险因素。帕金森病患者应筛查T2DM，并应及时开始治疗。对于导致这些疾病相互作用的分子机制，仍然缺乏了解。
