Zenchenko A A, Semenova Yu D, Naberezhnaya E R, Gumennaya Ya D, Lipatova A V, Oslovsky V E
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Dokl Biochem Biophys. 2025 Feb;520(1):38-41. doi: 10.1134/S1607672924600787. Epub 2025 Jan 22.
In this work, two new compounds, N-(4,5-dimethoxyphenyl)adenine and N-(3,5-di-trifluoromethylphenyl)adenine, with a broad range of antiviral activity against RNA viruses were identified. We showed that these compounds exhibit pronounced antiviral activity against human poliovirus types 1, 2, and 3, belonging to enterovirus C species. Both compounds also demonstrated pronounced antiviral activity against Coxsackie viruses B3, B5, and B6, belonging to enterovirus B species. In addition, the compounds demonstrated antiviral activity against Newcastle disease virus, which belongs to the paramyxovirus genus. The compounds discovered in this work can subsequently serve as prototypes for the development of new antiviral drugs against epidemiologically significant human RNA viruses.
在这项研究中，鉴定出了两种新化合物，即N-(4,5-二甲氧基苯基)腺嘌呤和N-(3,5-二-三氟甲基苯基)腺嘌呤，它们对RNA病毒具有广泛的抗病毒活性。我们发现这些化合物对属于肠道病毒C种的人脊髓灰质炎病毒1型、2型和3型表现出显著的抗病毒活性。这两种化合物对属于肠道病毒B种的柯萨奇病毒B3、B5和B6也表现出显著的抗病毒活性。此外，这些化合物对属于副粘病毒属的新城疫病毒也具有抗病毒活性。这项研究中发现的化合物随后可作为开发针对具有流行病学意义的人类RNA病毒的新型抗病毒药物的原型。
