Olkhovik D M, Silkina M O, Razumovskaya A V, Klycheva K V, Fatkulin A A, Kulagin T A, Nikulin S V
National Research University Higher School of Economics, Moscow, Russia.
Dokl Biochem Biophys. 2025 Feb;520(1):25-28. doi: 10.1134/S160767292460132X. Epub 2025 Jan 22.
Ferroptosis is an iron-dependent form of programmed cell death (PCD) associated with lipid membrane peroxidation. It has gained attention in cancer research because some tumor cells that are resistant to other forms of PCD are sensitive to ferroptosis. Despite the significant amount of research on ferroptosis, the list of known inducers remains limited, creating opportunities to discover new compounds with clinical potential. Recent studies have shown that long-chain polyunsaturated fatty acids, such as omega-3 docosahexaenoic acid (DHA), can function as ferroptosis inducers. In this study, we examined the kinetics of ferroptosis in prostate and colorectal cancer cells under the influence of erastin and DHA. Differences in the kinetics and mechanisms of action were observed. Moreover, cells resistant to erastin were found to be sensitive to DHA, confirming the potential of further research into its use as an anticancer agent.
铁死亡是一种与脂质膜过氧化相关的铁依赖性程序性细胞死亡（PCD）形式。它在癌症研究中受到关注，因为一些对其他形式PCD具有抗性的肿瘤细胞对铁死亡敏感。尽管对铁死亡进行了大量研究，但已知诱导剂的清单仍然有限，这为发现具有临床潜力的新化合物创造了机会。最近的研究表明，长链多不饱和脂肪酸，如ω-3二十二碳六烯酸（DHA），可以作为铁死亡诱导剂。在本研究中，我们研究了在埃拉司亭和DHA影响下前列腺癌和结肠癌细胞中铁死亡的动力学。观察到了动力学和作用机制的差异。此外，发现对埃拉司亭耐药的细胞对DHA敏感，这证实了进一步研究其作为抗癌剂用途的潜力。
