Kersten L, Barth A
Acta Physiol Hung. 1985;65(2):129-35.
The influence of a three-day lithium treatment on the biliary electrolyte and bile acid output was determined in 20- and 105-day-old rats. The osmolarity of bile and the biliary concentrations of cations (Na+, K+, Ca++, H+) and chloride were higher in untreated young rats than in adults, although bile flow and bile acid excretion rates of the young and adult animals were comparable. Lithium increased the biliary excretion of sodium, potassium and calcium and decreased the excretion of chloride and bicarbonate ions in both age groups. In contrast, lithium treatment reduced bile acid excretion only in adult rats. The lithium-induced alterations in biliary ion elimination may be caused by an intracellular replacement of sodium and/or potassium. These results indicate that after lithium treatment cation loss occurs in the young as well as in the adult organism not only via urine and faeces but also via bile.
在20日龄和105日龄的大鼠中，测定了为期三天的锂治疗对胆汁电解质和胆汁酸分泌量的影响。未接受治疗的幼鼠胆汁的渗透压以及胆汁中阳离子（Na +、K +、Ca ++、H +）和氯离子的浓度高于成年大鼠，尽管幼鼠和成年动物的胆汁流量和胆汁酸排泄率相当。锂增加了两个年龄组中钠、钾和钙的胆汁排泄，并减少了氯离子和碳酸氢根离子的排泄。相反，锂治疗仅降低了成年大鼠的胆汁酸排泄。锂诱导的胆汁离子消除变化可能是由细胞内钠和/或钾的替代引起的。这些结果表明，锂治疗后，幼鼠和成年生物体中的阳离子不仅通过尿液和粪便，还通过胆汁流失。
