巴西圣保罗登革热病毒3型（DENV-3）再次出现的早期见解。

Early insights of dengue virus serotype 3 (DENV-3) re-emergence in São Paulo, Brazil.

作者信息

Sacchetto Lívia, Bernardi Victória, Brancini Marini L, Marques Beatriz de C, Negri Andreia, Vasilakis Nikos, Estofolete Cassia F, Nogueira Maurício L

机构信息

Departmento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil.

Departamento de Vigilância Epidemiológica, São José do Rio Preto, São Paulo, Brazil.

出版信息

J Clin Virol. 2025 Feb;176:105763. doi: 10.1016/j.jcv.2025.105763. Epub 2025 Jan 15.

DOI:10.1016/j.jcv.2025.105763

PMID:39848015

Abstract

BACKGROUND

In dengue hyperendemic regions, the evolution of the virus is marked by frequent virus introduction/reintroduction and clade replacement events, occasionally linked to an epidemic outbreak. From 2023 onwards, an increase in the detection of DENV-3 cases has been reported in different regions of Brazil. Thus, molecular and genomic surveillance of circulating DENV strains is crucial for public health preparedness and response efforts for the disease.

OBJECTIVES

This work aimed to characterize and provide preliminary insights into dengue virus serotype 3 (DENV-3) re-emergence in São Paulo state, Brazil.

STUDY DESIGN

We conducted active arbovirus molecular surveillance on samples from patients with acute febrile illness combined with next-generation sequencing and phylogenetic analyses.

RESULTS

We detected and characterized DENV-3 circulation in São Paulo, Brazil, since late 2023. The genomes clustered within genomes recently (2022-2024) identified in Florida, the Caribbean region, and Brazil.

CONCLUSIONS

Our results demonstrate the resurgence of DENV-3 in the region since 2009, raising concerns about a potential outbreak in regions with a high epidemic history.

摘要