Huang Yingying, Zhou Xin, Liu Jiaqi, Cao Ying, Fu Wei, Yang Jing
School of Life Sciences, Peking University Third Hospital Cancer Center, Center for Life Sciences, State Key Laboratory of Membrane Biology, IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
School of Life Sciences, Peking University Third Hospital Cancer Center, Center for Life Sciences, State Key Laboratory of Membrane Biology, IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China; Department of General Surgery, Peking University Third Hospital, Beijing, 100191, China.
Cancer Lett. 2025 Mar 1;612:217492. doi: 10.1016/j.canlet.2025.217492. Epub 2025 Jan 21.
It has become increasingly recognized that neural signals can profoundly influence the prognosis of various cancer types. In the past years, we have witnessed "cancer neuroscience," which primarily focuses on the complex crosstalk between tumors and neural signals, emerging as a new, multidisciplinary direction of biomedical science. This review aims to summarize the current knowledge of this research frontier, with an emphasis on the neuroimmune mechanisms enacted through the reciprocal interactions between tumors and the central or peripheral nervous system. In addition, we wish to highlight several key questions of cancer neuroscience and its neuroimmune action that warrant future research and translational efforts, including novel strategies for manipulating neural signals for antitumor immunotherapies, as well as managing cancer-related neurological or psychiatric complications.
人们越来越认识到神经信号可深刻影响各种癌症类型的预后。在过去几年中，我们见证了“癌症神经科学”的兴起，它主要关注肿瘤与神经信号之间的复杂相互作用，已成为生物医学科学一个新的多学科研究方向。本综述旨在总结这一研究前沿的当前知识，重点关注通过肿瘤与中枢或外周神经系统之间的相互作用所产生的神经免疫机制。此外，我们希望强调癌症神经科学及其神经免疫作用的几个关键问题，这些问题值得未来的研究和转化努力，包括操纵神经信号用于抗肿瘤免疫治疗的新策略，以及管理癌症相关的神经或精神并发症。
