Miyazaki T, Ogawa S, Sakurai K, Mori H, Yamazaki H, Nakamura Y
Am J Cardiol. 1985 Apr 1;55(8):1085-90. doi: 10.1016/0002-9149(85)90751-9.
The effects of antiarrhythmic agents on automatic ventricular tachycardia (VT), which emerged in the early stage of acute myocardial infarction (AMI), were examined in 30 closed-chest mongrel dogs. Antiarrhythmic agents were administered intravenously when the rate of VT became almost equal to sinus rate (5.6 +/- 1.4 hours). VT was slowed significantly by verapamil (0.15 or 0.3 mg/kg), diltiazem (0.2 or 0.4 mg/kg), propranolol (0.1 mg/kg) and amiodarone (5 mg/kg), but not by procainamide (20 mg/kg), lidocaine (2 or 4 mg/kg), nifedipine (0.01 mg/kg) and nicorandil (0.03 mg/kg). The number of ventricular premature complexes was reduced most effectively by verapamil. The significant suppressive effects of calcium antagonist drugs (verapamil and diltiazem) and propranolol indicate that an inward calcium current during diastole may play a critical role in the abnormal enhancement of ventricular automaticity in the early stage (4 to 8 hours) of AMI.
在30只闭胸杂种犬身上研究了抗心律失常药物对急性心肌梗死（AMI）早期出现的室性心动过速（VT）的影响。当VT的速率几乎等于窦性速率时（5.6±1.4小时）静脉给予抗心律失常药物。维拉帕米（0.15或0.3mg/kg）、地尔硫䓬（0.2或0.4mg/kg）、普萘洛尔（0.1mg/kg）和胺碘酮（5mg/kg）可显著减慢VT，但普鲁卡因胺（20mg/kg）、利多卡因（2或4mg/kg）、硝苯地平（0.01mg/kg）和尼可地尔（0.03mg/kg）则不能。维拉帕米最有效地减少了室性早搏的数量。钙拮抗剂药物（维拉帕米和地尔硫䓬）和普萘洛尔的显著抑制作用表明，舒张期内向钙电流可能在AMI早期（4至8小时）心室自律性异常增强中起关键作用。
