Farhi D C, Mason U G, Horsburgh C R
Am J Clin Pathol. 1985 Apr;83(4):463-8. doi: 10.1093/ajcp/83.4.463.
Thirteen cases of disseminated Mycobacterium avium-intracellulare (MAI), representing a total of 27 bone marrow specimens, were studied. The patients ranged from 25 to 46 years of age and included ten immunocompromised and three immunocompetent hosts. Peripheral blood findings included anemia in all patients, leukopenia in 73%, thrombocytopenia in 45%, and pancytopenia in 45%. Fourteen of the specimens (52%) showed granulomas ranging from small, subtle lymphohistiocytic aggregates to larger lymphohistiocytic lesions and clusters of epithelioid histiocytes; almost half of these lesions were missed initially. Rare acid-fast bacilli were seen in only one case, but 53% grew MAI on culture. In one case of the acquired immunodeficiency syndrome, culture was positive in the absence of inflammation or AFB on staining. These findings are not significantly different from those reported in disseminated Mycobacterium tuberculosis infection.
对13例播散性鸟分枝杆菌-胞内分枝杆菌（MAI）病例进行了研究，共涉及27份骨髓标本。患者年龄在25至46岁之间，包括10例免疫功能低下者和3例免疫功能正常者。外周血检查结果显示，所有患者均有贫血，73%的患者有白细胞减少，45%的患者有血小板减少，45%的患者有全血细胞减少。14份标本（52%）显示有肉芽肿，范围从小的、细微的淋巴细胞组织细胞聚集到较大的淋巴细胞组织细胞病变以及上皮样组织细胞簇；几乎一半的这些病变最初被漏诊。仅1例可见罕见的抗酸杆菌，但53%的标本在培养时培养出MAI。在1例获得性免疫缺陷综合征患者中，培养呈阳性，而染色时无炎症或抗酸杆菌。这些发现与播散性结核分枝杆菌感染的报道结果无显著差异。
