Wang Yanfei, Huang Limin, Qian Junjie, Deng Kelei, Yang Zihao, Chen Zhenjie, Li Wei, Tan Linhua
Department of Surgical ICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Biomol Biomed. 2025 Aug 5;25(9):1972-1981. doi: 10.17305/bb.2024.11641.
Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia (CAP) in children and can lead to severe complications, including respiratory failure. A retrospective analysis of 2084 children diagnosed with CAP and treated in our hospital from January 2022 to January 2023 was conducted. A comprehensive dataset of patient demographics, clinical symptoms, and laboratory findings was initially assembled. Subsequent statistical analyses were carried out to elucidate the clinical characteristics of MP pneumonia (MPP) in children. Additionally, the study identified high-risk factors for respiratory failure in the context of MPP. Among the hospitalized MPP cases, 15.8% progressed to respiratory failure. Statistical analysis identified D-dimer level as a significant risk factor for respiratory failure in children with MPP. A predictive model was developed using D-dimer levels, yielding an area under the curve (AUC) of 0.818 with a cutoff value of 1.015 mg/L. The model demonstrated a sensitivity of 62.4% and a specificity of 91.3%, proving effective in predicting respiratory failure caused by MPP. Respiratory failure remains a critical complication in children with MPP, and D-dimer levels serve as a key predictive risk factor. Vigilant monitoring of coagulation function, particularly D-dimer levels, is essential for the early identification of patients at risk of developing respiratory failure in MPP cases.
肺炎支原体（MP）是儿童社区获得性肺炎（CAP）的常见病因，可导致包括呼吸衰竭在内的严重并发症。对2022年1月至2023年1月在我院诊断为CAP并接受治疗的2084例儿童进行了回顾性分析。最初收集了患者人口统计学、临床症状和实验室检查结果的综合数据集。随后进行了统计分析，以阐明儿童支原体肺炎（MPP）的临床特征。此外，该研究还确定了MPP背景下呼吸衰竭的高危因素。在住院的MPP病例中，15.8%进展为呼吸衰竭。统计分析确定D-二聚体水平是MPP患儿呼吸衰竭的一个重要危险因素。利用D-二聚体水平建立了一个预测模型，曲线下面积（AUC）为0.818，临界值为1.015mg/L。该模型的敏感性为62.4%，特异性为91.3%，在预测MPP引起的呼吸衰竭方面证明是有效的。呼吸衰竭仍然是MPP患儿的一种关键并发症，D-二聚体水平是一个关键的预测危险因素。密切监测凝血功能，尤其是D-二聚体水平，对于早期识别MPP病例中有发生呼吸衰竭风险的患者至关重要。
