Zhou Fangye, Yang Sen, Zhang Wenchang, Huang Min
Chengdu Fifth People's Hospital, Chengdu University of T.C.M, Chengdu, Sichuan, China.
Sci Rep. 2025 Aug 3;15(1):28306. doi: 10.1038/s41598-025-13555-6.
Mycoplasma pneumonia pneumonia(MPP) is a common respiratory disease that often occurs in children. The purpose of this study was to explore the clinical characteristics of children with mycoplasma pneumoniae pneumonia, the first outbreak after the prevalence of COVID-19 epidemic. Meanwhile, this study also analyzed the predictive value of serum protein indicators and coagulation parameters in the MPP group, as well as the correlation between these indicators. Children with Mycoplasma pneumoniae admitted to the pediatric ward of Chengdu Fifth People's Hospital from May 2023 to March 2024 were selected. After screening, 411 children who met the research criteria were selected as the study subjects. All of the blood samples were tested for coagulation function, procalcitonin, serum protein and glucose among MPP group and control group. All data were processed for statistical analysis using GraphPad Prism 10.2.3. Comparison of the serum proteins and coagulation function between the MPP group and control group showed that prothrobin time(PT), thrombin time (TT), fibrinogen(Fbg), activated partial thromboplastin time (APTT), international normalized ration(INR), D-Dimer(DD) were significantly higher(P < 0.05) in MPP group. Total protein, albumin, prealbumin, alkaline phosphatase, lactate dehydrogenase, adanosine deaminase, glucose, platelet, procalcitonin also were significantly higher(P < 0.05) in MPP group. A multiple logistic regression analysis showed that the children in MPP group were a statistically significant difference in comparison of TT, Fbg, total protein, albumin, glucose, platelet expression in predicting the development. Then we analyzed the area under the ROC curve and correlation of serum parameters with significant differences in MPP group children. These results indicate that the coagulation function and serum protein of MPP patients who first broke out after the COVID-19 epidemic are different from the previous clinical characteristics, which can be used as a reference for auxiliary diagnosis.
支原体肺炎（MPP）是一种常见于儿童的呼吸道疾病。本研究旨在探讨新型冠状病毒肺炎疫情流行后首次爆发的儿童支原体肺炎的临床特征。同时，本研究还分析了MPP组血清蛋白指标和凝血参数的预测价值，以及这些指标之间的相关性。选取2023年5月至2024年3月在成都市第五人民医院儿科病房收治的支原体肺炎患儿。经筛选，选取411例符合研究标准的患儿作为研究对象。对MPP组和对照组所有血样进行凝血功能、降钙素原、血清蛋白和血糖检测。所有数据采用GraphPad Prism 10.2.3进行统计分析。MPP组与对照组血清蛋白和凝血功能比较显示，MPP组凝血酶原时间（PT）、凝血酶时间（TT）、纤维蛋白原（Fbg）、活化部分凝血活酶时间（APTT）、国际标准化比值（INR）、D-二聚体（DD）显著升高（P＜0.05）。MPP组总蛋白、白蛋白、前白蛋白、碱性磷酸酶、乳酸脱氢酶、腺苷脱氨酶、葡萄糖、血小板、降钙素原也显著升高（P＜0.05）。多因素logistic回归分析显示，MPP组患儿在TT、Fbg、总蛋白、白蛋白、葡萄糖、血小板表达预测病情发展方面存在统计学差异。然后分析了MPP组患儿有显著差异的血清参数的ROC曲线下面积及相关性。这些结果表明，新型冠状病毒肺炎疫情后首次爆发的MPP患者的凝血功能和血清蛋白与以往临床特征不同，可作为辅助诊断的参考。
